Global Patent Index - EP 1161534 A1

EP 1161534 A1 2001-12-12 - DIFFERENTIAL EXPRESSION OF ORGANELLAR GENE PRODUCTS

Title (en)

DIFFERENTIAL EXPRESSION OF ORGANELLAR GENE PRODUCTS

Title (de)

DIFFERENTIELLE GENEXPRESSION VON GENPRODUKTEN AUS ZELLORGANELLEN

Title (fr)

EXPRESSION DIFFERENTIELLE DE PRODUITS GENIQUES D'ORGANITES

Publication

EP 1161534 A1 (EN)

Application

EP 00918143 A

Priority

  • US 0007311 W
  • US 12467399 P
  • US 52697700 A

Abstract (en)

[origin: WO0055323A1] Compositions and methods are provided for identifying factors, including organellar factors, that are differentially expressed when cells in different states, such as metabolic, respiratory, disease or apoptotic states, are compared. In preferred embodiments the invention relates to mitochondria DNA depleted ( rho <0>) and cytoplasmic hybrid (cybrid) cells, such as mitochondrial cybrid cells. Use of the invention to identify species specific expression of organellar factors such as organelle associated macromolecules is contemplated. Also disclosed are examples of organellar factors that are differentially expressed in organelle associated disease, including a variety of human genes that are differentially expressed in Alzheimer's disease.

IPC 1-7 (main, further and additional classification)

C12N 15/12; C07K 14/47; C12N 5/10; C12N 15/10; C12Q 1/68; G01N 33/53

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/12 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01)

CPC (invention and additional information)

C12N 15/1072 (2013.01); C07K 14/47 (2013.01); C07K 14/4711 (2013.01)

Citation (search report)

See references of WO 0055323A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0055323 A1 20000921; WO 0055323 A9 20011115; AU 3900600 A 20001004; CA 2363496 A1 20000921; EP 1161534 A1 20011212; JP 2003524397 A 20030819

INPADOC legal status


2005-04-20 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20041001

2001-12-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010920

2001-12-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI