EP 1161534 A1 20011212 - DIFFERENTIAL EXPRESSION OF ORGANELLAR GENE PRODUCTS
Title (en)
DIFFERENTIAL EXPRESSION OF ORGANELLAR GENE PRODUCTS
Title (de)
DIFFERENTIELLE GENEXPRESSION VON GENPRODUKTEN AUS ZELLORGANELLEN
Title (fr)
EXPRESSION DIFFERENTIELLE DE PRODUITS GENIQUES D'ORGANITES
Publication
Application
Priority
- US 0007311 W 20000316
- US 12467399 P 19990316
- US 52697700 A 20000315
Abstract (en)
[origin: WO0055323A1] Compositions and methods are provided for identifying factors, including organellar factors, that are differentially expressed when cells in different states, such as metabolic, respiratory, disease or apoptotic states, are compared. In preferred embodiments the invention relates to mitochondria DNA depleted ( rho <0>) and cytoplasmic hybrid (cybrid) cells, such as mitochondrial cybrid cells. Use of the invention to identify species specific expression of organellar factors such as organelle associated macromolecules is contemplated. Also disclosed are examples of organellar factors that are differentially expressed in organelle associated disease, including a variety of human genes that are differentially expressed in Alzheimer's disease.
IPC 1-7
C12N 15/12; C12N 15/10; C12N 5/10; C12Q 1/68; C07K 14/47; G01N 33/53
IPC 8 full level
A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/12 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); C07K 14/47 (2013.01); C07K 14/4711 (2013.01); C12N 15/1072 (2013.01)
Citation (search report)
See references of WO 0055323A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0055323 A1 20000921; WO 0055323 A9 20011115; AU 3900600 A 20001004; CA 2363496 A1 20000921; EP 1161534 A1 20011212; JP 2003524397 A 20030819
DOCDB simple family (application)
US 0007311 W 20000316; AU 3900600 A 20000316; CA 2363496 A 20000316; EP 00918143 A 20000316; JP 2000605741 A 20000316