Global Patent Index - EP 1162887 A4

EP 1162887 A4 20030625 - RECOMBINANT ADENO-ASSOCIATED VIRUS TRANSFER OF GENES AFFECTING DEMYELINATION

Title (en)

RECOMBINANT ADENO-ASSOCIATED VIRUS TRANSFER OF GENES AFFECTING DEMYELINATION

Title (de)

REKOMBINANTER ADENO-ASSOZIIERTER VIRUS TRANSFER VON DIE DEMYELINATION BEEINFLUSSENDEN GENEN

Title (fr)

TRANSFERT DE GENES PAR VIRUS ADENO-ASSOCIE RECOMBINE INFLUANT SUR LA DEMYELINISATION

Publication

EP 1162887 A4 20030625 (EN)

Application

EP 00914979 A 20000315

Priority

  • US 0006839 W 20000315
  • US 12439899 P 19990315

Abstract (en)

[origin: WO0054595A1] Disclosed are methods for the use of recombinant adeno-associated virus compositions. In particular, the use of catalase- or superoxide dismutase-expressing rAAV constructs in compositions for delivery to the optic nerve is disclosed. Also disclosed are methods for the treatment and amelioration of symptoms of demyelinating disorders of an animal, such as multiple sclerosis, allergic encephaloneuritis and optic neuritis.

IPC 1-7

A01N 63/00; A01N 43/04; C07H 21/02; C07H 21/04; C12N 15/00; C12N 15/09; C12N 15/63; C12N 15/70; C12N 15/74

IPC 8 full level

C12N 15/864 (2006.01)

CPC (source: EP)

C12N 15/86 (2013.01); C12N 2750/14143 (2013.01)

Citation (search report)

  • [X] WO 9534670 A2 19951221 - CHILDRENS HOSPITAL INC [US]
  • [XY] WO 9528493 A1 19951026 - UNIV ROCKEFELLER [US], et al
  • [Y] VAN DER VEEN ROEL C ET AL: "Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids.", JOURNAL OF NEUROIMMUNOLOGY, vol. 95, no. 1-2, 1 March 1999 (1999-03-01), pages 1 - 7, XP001120096, ISSN: 0165-5728
  • [Y] QI XIAOPING ET AL: "Increase of manganese superoxide dismutase, but not of Cu/Zn-SOD, in experimental optic neuritis.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 38, no. 6, 1997, pages 1203 - 1212, XP009001342, ISSN: 0146-0404
  • [A] ROSEN D R ET AL: "Mutations in copper-zinc superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 362, no. 6415, 1993, pages 59 - 62, XP002204594, ISSN: 0028-0836
  • [A] ROWLAND L P: "Amyotrophic lateral sclerosis: human challenge for neuroscience.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 28 FEB 1995, vol. 92, no. 5, 28 February 1995 (1995-02-28), pages 1251 - 1253, XP002237399, ISSN: 0027-8424
  • [PX] GUY J ET AL: "rAAV mediated gene transfer of catalase suppresses optic neuritis in transgenic ECSOD mice sensitized for experimental allergic encephalomyelitis (EAE).", IOVS, vol. 40, no. 4, 15 March 1999 (1999-03-15), Annual Meeting of the Association for Research in Vision and Ophthalmology;Fort Lauderdale, Florida, USA; May 9-14, 1999, pages S446, XP009001280
  • [T] GUY J ET AL: "Viral mediated gene transfer of MnSOD suppresses, while Cu/Zn SOD exacerbates experimental optic neuritis.", IOVS, vol. 41, no. 4, 15 March 2000 (2000-03-15), Annual Meeting of the Association for Research in Vision and Ophthalmology.;Fort Lauderdale, Florida, USA; April 30-May 05, 2000, pages S129, XP001119816
  • See references of WO 0054595A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0054595 A1 20000921; AU 3629200 A 20001004; CA 2367648 A1 20000921; EP 1162887 A1 20011219; EP 1162887 A4 20030625

DOCDB simple family (application)

US 0006839 W 20000315; AU 3629200 A 20000315; CA 2367648 A 20000315; EP 00914979 A 20000315