Global Patent Index - EP 1162958 A1

EP 1162958 A1 2001-12-19 - MACROMOLECULAR PHARMACEUTICAL AGENT SOLUBILIZED IN AEROSOL PROPELLANT

Title (en)

MACROMOLECULAR PHARMACEUTICAL AGENT SOLUBILIZED IN AEROSOL PROPELLANT

Title (de)

IN AEROSOLTREIBMITTEL AUFGELÖSTER MAKROMOLEKULARER ARZNEISTOFF

Title (fr)

AGENT PHARMACEUTIQUE DISSOUT DANS UN PROPULSEUR D'AEROSOL

Publication

EP 1162958 A1 (EN)

Application

EP 00908880 A

Priority

  • CA 0000260 W
  • US 27256399 A
  • US 38834499 A

Abstract (en)

[origin: WO0056291A1] A formulation with a pharmaceutical agent solubilized in a propellant can be administered buccally or into the lungs using a metered dose spray applicator. The pharmaceutical agent is dispensed from a pressurized container containing a stable solubilized mixture of propellant which is liquid under pressure and an intermediate formulation. The intermediate formulation comprises the proteinic pharmaceutical agent, water, first ingredient, second ingredient and at least one third ingredient. The first ingredient is glycerin and/or polyglycerin in an amount of from 1-50 wt./wt.% of the intermediate formulation. The second ingredient is phenol and/or methyl phenol in an amount of from 1-20 wt./wt.% of the intermediate formulation. Each third ingredient is selected from the group consisting of alkali metal C8 to C22 alkyl sulphate, polidocanol C6 to C40 alkyl ethers, trihydroxy sodium oxo-cholanyl glycines, polyoxyethylene sorbitanethers, alkyl-aryl polyether alcohols, hyaluronic acid and pharmaceutically suitable salts thereof, monoolein, triolein, lysine, polylysine, oleic acid, linoleic acid, linolenic acid, monooleates and laurates, glycolic acid, lactic acid, chenodeoxycholate, deoxycholate, chamomile extract, cucumber extract, borage oil and evening of primrose oil and mixtures thereof, in an amount of from 1-50 wt./wt.% of the intermediate formulation. The total concentration of first, second and third ingredients is less than 90 wt./wt.% of the intermediate formulation.

IPC 1-7 (main, further and additional classification)

A61K 9/72; A61K 38/28

IPC 8 full level (invention and additional information)

A61K 9/12 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01); A61K 38/28 (2006.01); A61K 47/08 (2006.01); A61K 47/12 (2006.01); A61K 47/20 (2006.01); A61K 47/28 (2006.01); A61K 47/34 (2006.01); A61K 47/36 (2006.01); A61K 47/46 (2006.01); A61M 11/00 (2006.01)

CPC (invention and additional information)

A61K 9/008 (2013.01); A61K 38/28 (2013.01)

Citation (search report)

See references of WO 0056291A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0056291 A1 20000928; AU 3140000 A 20001009; AU 766745 B2 20031023; CA 2364610 A1 20000928; CA 2364610 C 20061219; EP 1162958 A1 20011219; MX PA01009466 A 20020514; NZ 514319 A 20021126

INPADOC legal status


2005-03-23 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040914

2004-04-14 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040302

2001-12-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20011011

2001-12-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-19 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI