Global Patent Index - EP 1163203 A1

EP 1163203 A1 2001-12-19 - CRYSTALLINE HYDRATED DIHYDROXY OPEN-ACID SIMVASTATIN CALCIUM SALT

Title (en)

CRYSTALLINE HYDRATED DIHYDROXY OPEN-ACID SIMVASTATIN CALCIUM SALT

Title (de)

WASSERHALTIGES, KRISTALLINES CALCIUM-SALZ DER SIMVASTATIN DIHYDROXY OFFENE SÄURE

Title (fr)

SEL DE CALCIUM HYDRATE ET CRISTALLIN DE SIMVASTATINE D'ACIDE OUVERT EN DIHYDROXY

Publication

EP 1163203 A1 (EN)

Application

EP 00904644 A

Priority

  • US 0002627 W
  • US 12324799 P
  • US 26474599 A

Abstract (en)

[origin: EP1036783A1] The instant invention provides crystalline hydrates of the calcium salt of dihydroxy open acid simvastatin which are useful for inhibiting HMG-CoA reductase, and for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase. A process for making a specific crystalline hydrate of the calcium salt of dihydroxy open acid simvastatin is described. Conventional formulations, including rapid-release, time controlled-release and delayed-release formulations, of the active agents are also provided. <IMAGE>

IPC 1-7 (main, further and additional classification)

C07C 69/30; A61K 31/22; A61P 3/06; C07C 67/28

IPC 8 full level (invention and additional information)

A61K 9/00 (2006.01); A61K 9/52 (2006.01); A61K 31/22 (2006.01); A61K 47/08 (2006.01); A61K 47/10 (2006.01); A61K 47/14 (2006.01); A61P 3/06 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07C 67/28 (2006.01); C07C 67/52 (2006.01); C07C 69/30 (2006.01); C07D 309/30 (2006.01)

CPC (invention and additional information)

C07D 309/30 (2013.01); A61K 31/22 (2013.01); C07C 69/30 (2013.01); A61K 9/0004 (2013.01); C07C 2602/28 (2017.05)

Citation (search report)

See references of WO 0053566A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

EP 1036783 A1 20000920; EP 1036783 B1 20030521; AR 022857 A1 20020904; AT 240934 T 20030615; AU 2637000 A 20000928; AU 764048 B2 20030807; CA 2365869 A1 20000914; CO 5150184 A1 20020429; DE 60002769 D1 20030626; DE 60002769 T2 20040318; DE 60002769 T9 20041104; DK 1036783 T3 20030623; EP 1163203 A1 20011219; ES 2198253 T3 20040201; HN 2000000031 A 20010925; JP 2000281626 A 20001010; JP 2002539108 A 20021119; PE 14692000 A1 20001218; PT 1036783 E 20030829; SI 1036783 T1 20030831; SV 2002000035 A 20020115; WO 0053566 A1 20000914

INPADOC legal status


2004-01-02 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20030613

2003-01-15 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20021202

2001-12-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20011008

2001-12-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-19 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20011008;LT PAYMENT 20011008;LV PAYMENT 20011008;MK PAYMENT 20011008;RO PAYMENT 20011008;SI PAYMENT 20011008