EP 1163514 A1 20011219 - AN $i(IN VIVO) AND $i(IN VITRO) MODEL FOR CUTANEOUS PHOTOAGING AND OXIDATIVE DAMAGE
Title (en)
AN $i(IN VIVO) AND $i(IN VITRO) MODEL FOR CUTANEOUS PHOTOAGING AND OXIDATIVE DAMAGE
Title (de)
IN VIVO UND INVITRO MODELL FÜR DIE LICHTÄLTERUNG UND DURCHLICHTENTSTANDENOXIDATIVE SCHÄDIGUNG DER HAUT
Title (fr)
MODELE IN VIVO ET IN VITRO POUR PHOTOVIEILLISSEMENT CUTANE ET DESTRUCTION OXYDATIVE
Publication
Application
Priority
- US 0004703 W 20000222
- US 12026999 P 19990224
Abstract (en)
[origin: WO0050892A1] Transgenic hairless mice which express a full length or truncated human elastin promoter and fibroblast cultures derived from these transgenic mice are provided. Also provided are methods of identifying compounds capable of inhibiting cutaneous photodamage with these transgenic hairless mice or fibroblast cultures derived from these mice. In addition, an in vitro system for identifying agents capable of inhibiting or preventing oxidative damage in these mice fibroblast culture wherein reactive oxygen species are generated within the mouse fibroblast culture and a method for identifying agents which prevent oxidative damage are provided.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 49/00 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); A61K 49/0004 (2013.01); A61K 49/0008 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0393 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0050892 A1 20000831; AU 3375400 A 20000914; AU 761728 B2 20030605; CA 2362585 A1 20000831; EP 1163514 A1 20011219; EP 1163514 A4 20020918; JP 2002542764 A 20021217
DOCDB simple family (application)
US 0004703 W 20000222; AU 3375400 A 20000222; CA 2362585 A 20000222; EP 00911941 A 20000222; JP 2000601437 A 20000222