Global Patent Index - EP 1165059 A4

EP 1165059 A4 20030305 - PHARMACEUTICAL COMPOSITIONS COMPRISING TROPONIN SUBUNITS, FRAGMENTS AND HOMOLOGS THEREOF AND METHODS OF THEIR USE TO INHIBIT ANGIOGENESIS

Title (en)

PHARMACEUTICAL COMPOSITIONS COMPRISING TROPONIN SUBUNITS, FRAGMENTS AND HOMOLOGS THEREOF AND METHODS OF THEIR USE TO INHIBIT ANGIOGENESIS

Title (de)

PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DIE UNTEREINHEITEN VON TROPONIN, FRAGMENTE DAVON UND DEREN HOMOLOGE ENTHALTEN UND METHODEN ZU IHRER VERWENDUNG ZUR INHIBITION VON ANGIOGENESE

Title (fr)

COMPOSITIONS PHARMACEUTIQUES RENFERMANT DES SOUS-UNITES DE TROPONINE, OU DES FRAGMENTS OU DES HOMOLOGUES DESDITES SOUS-UNITES, ET LEUR UTILISATION POUR INHIBER L'ANGIOGENESE

Publication

EP 1165059 A4 20030305 (EN)

Application

EP 00916329 A 20000314

Priority

  • US 0006667 W 20000314
  • US 26827499 A 19990315
  • US 44209999 A 19991117

Abstract (en)

[origin: WO0054770A1] The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of troponin C, I or T subunits, fragments or homologs for the treatment of diseases or disorders involving abnormal angiogenesis and methods of use thereof.

IPC 1-7

A61K 38/08; A61K 38/10; C07K 7/06; C07K 7/08; A61P 35/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 35/12 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61P 11/00 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07K 14/47 (2006.01)

CPC (source: EP)

A61K 38/1709 (2013.01); A61P 11/00 (2017.12); A61P 27/02 (2017.12); A61P 35/00 (2017.12); A61P 35/04 (2017.12); C07K 14/4716 (2013.01)

Citation (search report)

  • [X] WO 9730085 A1 19970821 - CHILDRENS MEDICAL CENTER [US]
  • [PX] MOSES M A ET AL: "Troponin I is present in human cartilage and inhibits angiogenesis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, 16 March 1999 (1999-03-16), pages 2645 - 2650, XP002131230, ISSN: 0027-8424
  • [T] FELDMAN LAURIE ET AL: "Troponin I inhibits capillary endothelial cell proliferation by interaction with the cell's bFGF receptor.", MICROVASCULAR RESEARCH, vol. 63, no. 1, January 2002 (2002-01-01), pages 41 - 49, XP002218582, ISSN: 0026-2862
  • [A] VALLINS W J ET AL: "MOLECULAR CLONING OF HUMAN CARDIAC TROPONIN I USING POLYMERASE CHAIN REACTION", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 270, no. 1/2, 17 September 1990 (1990-09-17), pages 57 - 61, XP000470204, ISSN: 0014-5793
  • See references of WO 0054770A1

Citation (examination)

  • JHA PRAKASH K. ET AL: "Photo-cross-linking of rabbit skeletal troponin I deletion mutants with troponin C and its thiol mutants: The inhibitory region enhances binding of troponin I fragments to troponin C", BIOCHEMISTRY, vol. 35, no. 34, 1996, pages 11026 - 11035
  • JHA PRAKASH K. ET AL: "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca-2+ sensitivity of the reconstituted regulatory system", BIOCHEMISTRY, vol. 35, no. 51, 1996, pages 16573 - 16580

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0054770 A1 20000921; WO 0054770 A8 20010111; AU 3744900 A 20001004; AU 774596 B2 20040701; CA 2367611 A1 20000921; EP 1165059 A1 20020102; EP 1165059 A4 20030305; JP 2002539161 A 20021119

DOCDB simple family (application)

US 0006667 W 20000314; AU 3744900 A 20000314; CA 2367611 A 20000314; EP 00916329 A 20000314; JP 2000604846 A 20000314