EP 1165084 A1 20020102 - INHIBITORS OF PRENYL-PROTEIN TRANSFERASES
Title (en)
INHIBITORS OF PRENYL-PROTEIN TRANSFERASES
Title (de)
INHIBITOREN DER PRENYL-PROTEINTRANSFERASEN
Title (fr)
INHIBITEURS DE PRENYL-PROTEINE TRANSFERASES
Publication
Application
Priority
- US 0005354 W 20000301
- US 12297199 P 19990303
- US 12725299 P 19990331
Abstract (en)
[origin: WO0051614A1] The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases. In particular, the invention relates to prenyl-protein transferase inhibitors which are efficacious in vivo as inhibitors of geranylgeranyl-protein transferase type I (GGTase-I) and that inhibit the cellular processing of both the H-Ras protein and the K4B-Ras protein. Such therapeutic compounds are useful in the treatment of cancer.
IPC 1-7
A61K 31/496; A61K 31/551; A61P 9/10; A61P 13/12; A61P 27/02; A61P 31/14; A61P 35/00; C12N 9/99; C07D 403/04; C07D 403/06; C07D 403/12; C07D 403/14
IPC 8 full level
A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 27/02 (2006.01); A61P 31/14 (2006.01); A61P 35/00 (2006.01); C07D 233/54 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01)
CPC (source: EP)
A61P 9/10 (2017.12); A61P 13/12 (2017.12); A61P 27/02 (2017.12); A61P 31/12 (2017.12); A61P 31/14 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 233/64 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0051614 A1 20000908; AU 3248600 A 20000921; CA 2362495 A1 20000908; EP 1165084 A1 20020102; EP 1165084 A4 20020515; JP 2002538121 A 20021112
DOCDB simple family (application)
US 0005354 W 20000301; AU 3248600 A 20000301; CA 2362495 A 20000301; EP 00910386 A 20000301; JP 2000602082 A 20000301