Global Patent Index - EP 1165111 A4

EP 1165111 A4 20041103 - METHOD FOR PR-39 PEPTIDE REGULATED STIMULATION OF ANGIOGENESIS

Title (en)

METHOD FOR PR-39 PEPTIDE REGULATED STIMULATION OF ANGIOGENESIS

Title (de)

VERFAHREN ZUR STIMULATION DER ANGIOGENESE DURCH REGULATION MITTELS PR-39 PEPTID

Title (fr)

METHODE DE STIMULATION DE L'ANGIOGENESE REGULEE PAR PEPTIDES PR-39

Publication

EP 1165111 A4 20041103 (EN)

Application

EP 00919442 A 20000316

Priority

  • US 0007050 W 20000316
  • US 27686899 A 19990326

Abstract (en)

[origin: WO0057895A1] The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homolog, for interaction with such proteasomes as one present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with proteasomes is a decrease in the intracellular degradation of active peptides such as HIF-1 alpha and a consequential stimulation of angiogenesis in-situ.

IPC 1-7

A61K 38/00; A61K 38/08; A61K 38/16; C07K 7/00; C07K 7/04; C07K 7/06

IPC 8 full level

C07K 14/81 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/8139 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [X] WO 9609322 A2 19960328 - CHILDRENS MEDICAL CENTER [US]
  • [X] WO 9632129 A1 19961017 - UNIV KANSAS STATE [US], et al
  • [X] LI J ET AL: "CARDIAC-SPECIFIC OVEREXPRESSION OF PR-39 INDUCES ANGIOGENESIS, MYOCARDIAL HYPERTROPHY AND INCREASED MICROVASCULAR REACTIVITY", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 98, no. 17, October 1998 (1998-10-01), pages 1794, XP002929855, ISSN: 0009-7322
  • [X] GAO Y ET AL: "PR39 INTERACTS WITH PROTEASOME AND MODULATES HIF-1ALPHA LEVEL IN ECV CELLS", MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. 9, no. SUPPL, November 1998 (1998-11-01), pages 123A, XP008033931, ISSN: 1059-1524
  • [X] LI J ET AL: "MACROPHAGE-DEPENDENT REGULATION OF SYNDECAN GENE EXPRESSION", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 81, no. 5, November 1997 (1997-11-01), pages 785 - 796, XP008033955, ISSN: 0009-7330
  • [PX] LI J ET AL: "PR39, a peptide regulator of angiogenesis", NATURE MEDICINE, NATURE AMERICA, NEW YORK, US, vol. 6, no. 1, January 2000 (2000-01-01), pages 49 - 55, XP002968105, ISSN: 1078-8956
  • [T] GAO Y ET AL: "Inhibition of ubiquitin-proteasome pathway-mediated I-kappaBalpha degradation by a naturally occuring antibacterial peptide", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 106, no. 3, August 2000 (2000-08-01), pages 439 - 448, XP002180614, ISSN: 0021-9738
  • See references of WO 0057895A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0057895 A1 20001005; AU 4013200 A 20001016; CA 2368638 A1 20001005; EP 1165111 A1 20020102; EP 1165111 A4 20041103

DOCDB simple family (application)

US 0007050 W 20000316; AU 4013200 A 20000316; CA 2368638 A 20000316; EP 00919442 A 20000316