Global Patent Index - EP 1165145 A4

EP 1165145 A4 20030305 - ANTISENSE MODULATION OF MDMX EXPRESSION

Title (en)

ANTISENSE MODULATION OF MDMX EXPRESSION

Title (de)

ANTISENSE-MODULATION DER MDMX-EXPRESSION

Title (fr)

REGULATION ANTISENS D'EXPRESSION DE MDMX

Publication

EP 1165145 A4 20030305 (EN)

Application

EP 99966631 A 19991223

Priority

  • US 9930846 W 19991223
  • US 28926799 A 19990409

Abstract (en)

[origin: WO0061193A1] Antisense compounds, compositions and methods are provided for modulating the expression of MDMX. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MDMX. Methods of using these compounds for modulation of MDMX expression and for treatment of diseases associated with expression of MDMX are provided.

IPC 1-7

A61K 48/00; C12N 15/85; C12N 15/86; C07H 21/04

IPC 8 full level

C12N 15/113 (2010.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)

CPC (source: EP US)

C12N 15/113 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); C12N 2310/315 (2013.01 - EP US); C12N 2310/321 (2013.01 - EP US); C12N 2310/3341 (2013.01 - EP US); C12N 2310/341 (2013.01 - EP US); C12N 2310/346 (2013.01 - EP US); Y02P 20/582 (2015.11 - EP US)

Citation (search report)

  • [Y] US 5411860 A 19950502 - VOGELSTEIN BERT [US], et al
  • [Y] WO 9910486 A2 19990304 - HYBRIDON INC [US], et al
  • [XY] DATABASE EBI [online] XP002222397, retrieved from EBI accession no. HSAF7111 Database accession no. AF007111 & SHVARTS, AVI ET AL: "Isolation and identification of the human homolog of a new p53-binding protein, Mdmx", GENOMICS, no. 43, 1997, pages 34 - 42, XP001119745
  • [XY] DATABASE EBI [online] XP002222398, retrieved from EBI accession no. A58681 Database accession no. A58681 & WO 9641875 A1 19961227 - INTROGENE BV [NL], et al
  • [Y] UHLMANN E ET AL: "ANTISENSE OLIGONUCLEOTIDES: A NEW THERAPEUTIC PRINCIPLE", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 90, no. 4, 1 June 1990 (1990-06-01), pages 543 - 584, XP000141412, ISSN: 0009-2665
  • [XDY] SHVARTS, AVI ET AL: "MDMX: a novel p53-binding protein with some functional properties of MDM2", EMBO JOURNAL, vol. 15, no. 19, 1996, pages 5349 - 5357, XP009000723
  • [Y] CHEN L ET AL: "Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, 6 January 1998 (1998-01-06), pages 195 - 200, XP002110693, ISSN: 0027-8424
  • See references of WO 0061193A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0061193 A1 20001019; AU 2213600 A 20001114; EP 1165145 A1 20020102; EP 1165145 A4 20030305; US 6046320 A 20000404

DOCDB simple family (application)

US 9930846 W 19991223; AU 2213600 A 19991223; EP 99966631 A 19991223; US 28926799 A 19990409