EP 1165502 A1 20020102 - DIARYL DERIVATIVES AND THEIR USE AS MEDICAMENTS
Title (en)
DIARYL DERIVATIVES AND THEIR USE AS MEDICAMENTS
Title (de)
DIARYLDERIVATE UND IHRE ANWENDUNG ALS ARZNEIMITTEL
Title (fr)
DERIVES DIARYLE ET UTILISATIONS DE CEUX-CI COMME MEDICAMENTS
Publication
Application
Priority
- EP 0002683 W 20000327
- US 28010599 A 19990329
Abstract (en)
[origin: WO0058279A1] Compounds of formula (I) in which W is O, S, S(O) or S(O)2; X is -SR4, -S(O)R4, or -S(O)2R4, -S(O)2NR5R6; or X is -C(O)NR5R6 provided that -C(O)NR5R6 is located at the 3', 4' or 5' position; Y is O or H2; Z is hydrogen, halogen, hydroxy, optionally substituted alkoxy, aralkoxy, acyloxy or alkoxycarbonyloxy; R is hydrogen, halogen, trifluoromethyl, lower alkyl or cycloalkyl; R1 is hydroxy, optionally substituted alkoxy, aryloxy, heteroarylocy, aralkyloxy, cycloalkoxy, heteroaralkoxy or -NR5R6; R2 is hydrogen, halogen or alkyl; R3 is halogen or alkyl; R4 is optionally substituted alkyl, aryl, aralkyl, heteroaralkyl or heteroaryl; R5, R6 and R7 are independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or R5 and R6 combined are alkylene optionally interrupted by O, S, S(O), S(O)2 or NR7 which together with the nitrogen atom to which they are attached form a 5- to 7- membered ring; n represents zero or an integer from 1 to 4; pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; a method to prevent and treat diseases associated with an imbalance of thyroid hormones, such as hypo-and hyperthyroidism, obesity, osteoporosis and depression; and, a method of lowering LDL cholesterol and Lp(a) levels in mammals using such compounds.
IPC 1-7
C07C 311/29; C07C 235/60; C07C 317/22; C07C 323/67; C07D 213/75; C07D 213/76; C07D 295/13; C07D 295/185; C07D 295/192; C07D 295/26; A61K 31/16; A61K 31/18; A61P 9/00
IPC 8 full level
A61K 31/167 (2006.01); A61K 31/192 (2006.01); A61K 31/4406 (2006.01); A61K 31/4412 (2006.01); A61K 31/4453 (2006.01); A61K 31/5375 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 5/14 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 19/10 (2006.01); A61P 25/24 (2006.01); C07D 295/12 (2006.01); C07C 235/60 (2006.01); C07C 311/29 (2006.01); C07C 317/22 (2006.01); C07C 323/67 (2006.01); C07D 213/75 (2006.01); C07D 213/76 (2006.01); C07D 295/13 (2006.01); C07D 295/18 (2006.01); C07D 295/185 (2006.01); C07D 295/192 (2006.01); C07D 295/26 (2006.01)
CPC (source: EP KR)
A61P 3/04 (2018.01 - EP); A61P 3/06 (2018.01 - EP); A61P 5/14 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 25/24 (2018.01 - EP); C07C 311/29 (2013.01 - EP KR); C07C 317/22 (2013.01 - EP KR); C07C 323/67 (2013.01 - EP KR); C07D 295/13 (2013.01 - EP KR); C07D 295/185 (2013.01 - EP KR); C07D 295/192 (2013.01 - EP KR); C07D 295/26 (2013.01 - EP); C07C 2601/14 (2017.05 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0058279 A1 20001005; AU 4290800 A 20001016; BR 0009431 A 20020108; CA 2361016 A1 20001005; CN 1345309 A 20020417; CO 5160290 A1 20020530; CZ 20013449 A3 20011212; EP 1165502 A1 20020102; HK 1042692 A1 20020823; HU P0200588 A2 20020729; IL 144637 A0 20020523; JP 2002540189 A 20021126; KR 20010105394 A 20011128; MX PA01009843 A 20020506; NO 20014702 D0 20010927; NO 20014702 L 20010927; NZ 514062 A 20010928; PE 20001587 A1 20010131; PL 349355 A1 20020715; RU 2001126579 A 20040227; SK 13812001 A3 20020404; TR 200102225 T2 20020121
DOCDB simple family (application)
EP 0002683 W 20000327; AU 4290800 A 20000327; BR 0009431 A 20000327; CA 2361016 A 20000327; CN 00805693 A 20000327; CO 00020338 A 20000322; CZ 20013449 A 20000327; EP 00922557 A 20000327; HK 02104536 A 20020618; HU P0200588 A 20000327; IL 14463700 A 20000327; JP 2000607982 A 20000327; KR 20017012250 A 20010926; MX PA01009843 A 20000327; NO 20014702 A 20010927; NZ 51406200 A 20000327; PE 0002602000 A 20000327; PL 34935500 A 20000327; RU 2001126579 A 20000327; SK 13812001 A 20000327; TR 200102225 T 20000327