EP 1165504 A2 20020102 - USE OF INHIBITORS OF LFA-1 BINDING TO ICAMs
Title (en)
USE OF INHIBITORS OF LFA-1 BINDING TO ICAMs
Title (de)
ANWENDUNG VON VERBINDUNGEN, WELCHE DIE BINDUNG VON LFA-1 AN ICAM HEMMEN
Title (fr)
UTILISATION DES INHIBITEURS DE LA LIAISON LFA-1 AUX ICAMS
Publication
Application
Priority
- US 0008840 W 20000403
- US 28532599 A 19990402
Abstract (en)
[origin: WO0059878A2] Novel compounds are disclosed that inhibit binding of LFA-1 to a natural ligand binding partner. Uses of the compounds are also provided.
[origin: WO0059878A2] The present invention is directed to compounds that bind to a novel regulatory site in the I domain of LFA-1, and thereby inhibit LFA-1 binding to ICAMs that bind LFA-1. The present invention therefore also provides methods to regulate leukocyte adhesion to endothelial cells. Compounds of the ivnention are useful for the treatment of pathologies, such as those associated inflammatory diseases, autoimmune diseases, tumor metastasis, allograft rejection and reperfusion injury. In particular, the present invention is directed to diaryl sulfides of general structural formula (I), a pharmaceutically acceptable salt, or prodrug thereof, and to the use of diaryl sulfides, and particularly compounds of formula (I), to inhibit LFA-1 binding to an ICAM that binds LFA-1 wherein A and B, independently, are aryl groups selected from the group consisting of 5- and 6-membered aromatic rings, including, but not limited to, phenyl, thienyl, furyl, pyrimidinyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrrolyl, and pyridazinyl.
IPC 1-7
C07C 323/37; C07C 323/09; C07D 213/70; C07D 295/12; C07D 215/36; C07C 323/41; C07D 235/06; C07C 323/32; C07C 323/65; A61K 31/135; A61K 31/04
IPC 8 full level
A61K 31/04 (2006.01); A61K 31/135 (2006.01); A61K 31/343 (2006.01); A61K 31/40 (2006.01); A61K 31/402 (2006.01); A61K 31/4184 (2006.01); A61K 31/428 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/5375 (2006.01); A61P 29/00 (2006.01); C07D 295/08 (2006.01); A61P 35/04 (2006.01); A61P 37/06 (2006.01); C07C 311/21 (2006.01); C07C 323/09 (2006.01); C07C 323/32 (2006.01); C07C 323/37 (2006.01); C07C 323/41 (2006.01); C07C 323/65 (2006.01); C07D 207/325 (2006.01); C07D 207/416 (2006.01); C07D 213/64 (2006.01); C07D 213/70 (2006.01); C07D 215/36 (2006.01); C07D 233/06 (2006.01); C07D 235/06 (2006.01); C07D 277/74 (2006.01); C07D 295/096 (2006.01); C07D 295/12 (2006.01); C07D 295/135 (2006.01); C07D 307/88 (2006.01); C07D 307/90 (2006.01); C07D 207/40 (2006.01)
CPC (source: EP KR)
A61P 19/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/06 (2018.01 - EP); C07C 323/09 (2013.01 - EP); C07C 323/37 (2013.01 - EP KR); C07C 323/41 (2013.01 - EP); C07D 207/416 (2013.01 - EP); C07D 213/70 (2013.01 - EP); C07D 215/36 (2013.01 - EP); C07D 235/06 (2013.01 - EP); C07D 277/74 (2013.01 - EP); C07D 295/096 (2013.01 - EP); C07D 295/135 (2013.01 - EP); C07D 307/90 (2013.01 - EP)
Citation (third parties)
Third party :
WO 9533750 A1 19951214 - PFIZER [US], et al
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 0059878 A2 20001012; WO 0059878 A3 20010809; AU 2004205210 A1 20040923; AU 4191900 A 20001023; AU 774054 B2 20040617; BG 106019 A 20020628; BR 0009421 A 20020326; CA 2369005 A1 20001012; CN 1351588 A 20020529; CN 1721401 A 20060118; CZ 20013524 A3 20020612; EA 200101017 A1 20020425; EE 200100514 A 20021216; EP 1165504 A2 20020102; HR P20010777 A2 20021231; HU P0201904 A2 20020928; HU P0201904 A3 20030428; IL 145528 A0 20020630; IS 6096 A 20010928; JP 2002541141 A 20021203; KR 20020003559 A 20020112; MX PA01009915 A 20030820; NO 20014768 D0 20011001; NO 20014768 L 20011129; NZ 515238 A 20050225; PL 351323 A1 20030407; SK 14022001 A3 20020305
DOCDB simple family (application)
US 0008840 W 20000403; AU 2004205210 A 20040824; AU 4191900 A 20000403; BG 10601901 A 20011016; BR 0009421 A 20000403; CA 2369005 A 20000403; CN 00807734 A 20000403; CN 200510079402 A 20000403; CZ 20013524 A 20000403; EA 200101017 A 20000403; EE P200100514 A 20000403; EP 00921626 A 20000403; HR P20010777 A 20011023; HU P0201904 A 20000403; IL 14552800 A 20000403; IS 6096 A 20010928; JP 2000609391 A 20000403; KR 20017012479 A 20010928; MX PA01009915 A 20000403; NO 20014768 A 20011001; NZ 51523800 A 20000403; PL 35132300 A 20000403; SK 14022001 A 20000403