Global Patent Index - EP 1165517 A1

EP 1165517 A1 20020102 - N-BENZIMIDAZOLYLMETHYL- AND N-INDOLYLMETHYL-BENZAMIDES AND THEIR USE AS CRF MODULATORS

Title (en)

N-BENZIMIDAZOLYLMETHYL- AND N-INDOLYLMETHYL-BENZAMIDES AND THEIR USE AS CRF MODULATORS

Title (de)

N-BENZIMIDAZOLYLMETHYL- UND N-INDOLYLMETHYL-BENZAMIDE UND IHRE VERWENDUNG ALS CRF MODULATOREN

Title (fr)

N-BENZIMIDAZOLYLMETHYL- ET N-INDOLYLMETHYL-BENZAMIDES ET LEUR APPLICATION COMME MODULATEURS DE CORTICOLIBERINE

Publication

EP 1165517 A1 20020102 (EN)

Application

EP 00918516 A 20000331

Priority

  • US 0008570 W 20000331
  • US 12762499 P 19990402
  • US 28542099 A 19990402

Abstract (en)

[origin: WO0059888A1] Disclosed are compounds of formula (I); or the pharmaceutically acceptable non-toxic salts thereof wherein; A is N or CH; R1 and R2 represents hydrogen or lower alkyl; G, R3, R4, R5, R6, R7 and R8 are variables defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorders, anxiety, depression, eating disorders, and stress disorders in humans and other animals. Methods of treatment of such disorders as well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

IPC 1-7

C07D 235/14; C07D 209/14; A61K 31/4184; A61K 31/4045; A61P 25/00; G01N 33/50

IPC 8 full level

A61K 31/4045 (2006.01); A61K 31/4184 (2006.01); A61P 3/04 (2006.01); A61P 7/12 (2006.01); A61P 25/00 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); C07D 209/14 (2006.01); C07D 235/14 (2006.01); C07D 235/10 (2006.01)

CPC (source: EP)

A61P 3/04 (2017.12); A61P 7/12 (2017.12); A61P 25/00 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); C07D 209/14 (2013.01); C07D 235/14 (2013.01); G01N 2333/726 (2013.01)

Citation (search report)

See references of WO 0059888A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0059888 A1 20001012; AU 3931400 A 20001023; CA 2369553 A1 20001012; EP 1165517 A1 20020102; JP 2003528802 A 20030930

DOCDB simple family (application)

US 0008570 W 20000331; AU 3931400 A 20000331; CA 2369553 A 20000331; EP 00918516 A 20000331; JP 2000609400 A 20000331