EP 1165598 A1 20020102 - HOOKWORM PLATELET INHIBITOR
Title (en)
HOOKWORM PLATELET INHIBITOR
Title (de)
INHIBITOR FÜR BLUTPLÄTTCHEN DES HAKENWURMS
Title (fr)
INHIBITEUR DES PLAQUETTES D'ANKYLOSTOME
Publication
Application
Priority
- US 0008519 W 20000330
- US 12723999 P 19990331
Abstract (en)
[origin: WO0058341A1] An inhibitor of platelet aggregation and adhesion is purified and characterized from soluble protein extracts of adult Ancylostoma caninum hookworms, and then cloned and sequenced. The inhibitor blocks platelet aggregation in response to a variety of agonists, interfering with the binding of at least one cell surface integrin with its respective ligand. Embodiments include inhibition of the binding of fibrinogen to cell surface integrin GPIIb/IIIa ( alpha IIb beta 3) and inhibition of the binding of collagen to cell surface integrin GPIa/IIa ( alpha 2 beta 1). Medical and veterinary pharmaceutical and immunological compositions containing the platelet inhibitor, and methods of using it, are described.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/56 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 7/02 (2006.01); A61P 33/10 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07K 14/435 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); A61P 33/10 (2017.12); A61P 37/04 (2017.12); A61P 43/00 (2017.12); C07K 14/4354 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0058341 A1 20001005; AU 3930800 A 20001016; CA 2367424 A1 20001005; EP 1165598 A1 20020102; EP 1165598 A4 20021030; JP 2002539817 A 20021126
DOCDB simple family (application)
US 0008519 W 20000330; AU 3930800 A 20000330; CA 2367424 A 20000330; EP 00918509 A 20000330; JP 2000608041 A 20000330