Global Patent Index - EP 1165752 A4

EP 1165752 A4 20030205 - AN ENGINEERED RECOMBINANT MOLECULE THAT REGULATES HUMORAL AND CELLULAR EFFECTOR FUNCTIONS OF THE IMMUNE SYSTEM

Title (en)

AN ENGINEERED RECOMBINANT MOLECULE THAT REGULATES HUMORAL AND CELLULAR EFFECTOR FUNCTIONS OF THE IMMUNE SYSTEM

Title (de)

REKOMBINANTES MOLEKÜL, WELCHES HUMORALE UND ZELLULÄRE EFFEKTORFUNKTIONEN DES IMMUNSYSTEMS REGULIERT

Title (fr)

MOLECULE DE RECOMBINAISON MODIFIEE REGULANT LES FONCTIONS EFFECTRICES HUMORALES ET CELLULAIRES DU SYSTEME IMMUNITAIRE

Publication

EP 1165752 A4 20030205 (EN)

Application

EP 00975335 A 20001021

Priority

  • US 0029151 W 20001021
  • US 16118699 P 19991022

Abstract (en)

[origin: WO0130966A2] Recombinant chimeric molecules that include at least a domain capable of regulating the humoral effector functions of the immune system and another domain capable of regulating the cellular effector functions of the immune system are provided. Recombinant DNA constructs having DNA sequences encoding the above mentioned chimeric proteins are provided. Cloning vectors incorporating the above DNA constructs and cells transformed with the vectors and host cells containing such vectors are also provided. Transgenic cells, tissues, organs, and animals incorporating the above-mentioned chimeric molecules are provided.

IPC 1-7

C12N 5/00; C12N 15/00; C12N 15/09; C12N 15/63; C07K 1/00; C07K 14/00; C07K 17/00; C07K 14/47; C12N 15/62

IPC 8 full level

C07K 14/705 (2006.01)

CPC (source: EP)

C07K 14/70521 (2013.01); C07K 14/70596 (2013.01); A01K 2217/05 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

  • [X] US 5844095 A 19981201 - LINSLEY PETER S [US], et al
  • [X] EP 0682039 A1 19951115 - BRISTOL MYERS SQUIBB CO [US]
  • [X] FODOR WILLIAM L ET AL: "A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex.", JOURNAL OF IMMUNOLOGY, vol. 155, no. 9, 1995, pages 4135 - 4138, XP000608498, ISSN: 0022-1767
  • [Y] GEISSLER M ET AL: "Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 16, no. 8, 1 May 1998 (1998-05-01), pages 857 - 867, XP004118495, ISSN: 0264-410X
  • [Y] ZHAO X J ET AL: "Identity of the residues responsible for the species-restricted complement inhibitory function of human CD59", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 17, 24 April 1998 (1998-04-24), pages 10665 - 10671, XP002105089, ISSN: 0021-9258
  • [PX] CRISTINA C ET AL: "Delayed rejection in a small animal model grafted with porcine cells expressing CTLA4-CD59 chimeric molecule to block pCD86.", XENOTRANSPLANTATION, vol. 8, no. Supplement 1, August 2001 (2001-08-01), VI Congress of the International Xenotransplantation Association;Chicago, Illinois, USA; September 29-October 03, 2001, pages 101, XP009002543, ISSN: 0908-665X
  • See references of WO 0130966A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0130966 A2 20010503; WO 0130966 A3 20011018; AU 1340101 A 20010508; CA 2361646 A1 20010503; EP 1165752 A2 20020102; EP 1165752 A4 20030205

DOCDB simple family (application)

US 0029151 W 20001021; AU 1340101 A 20001021; CA 2361646 A 20001021; EP 00975335 A 20001021