EP 1165779 A1 20020102 - A PRESENILIN ASSOCIATED MEMBRANE PROTEIN AND USES THEREOF
Title (en)
A PRESENILIN ASSOCIATED MEMBRANE PROTEIN AND USES THEREOF
Title (de)
EIN PRESENILIN ASSOZIIERTES MEMBRAN PROTEIN UND VERWENDUNGEN DAVON
Title (fr)
PROTEINE MEMBRANAIRE ASSOCIEE A LA PRESENILINE ET SES UTILISATIONS
Publication
Application
Priority
- CA 0000354 W 20000403
- US 12745299 P 19990401
- US 17382699 P 19991230
Abstract (en)
[origin: WO0060069A1] Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided, PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment, mutations in PAMP are diagnostic for Alzheimer's Disease or spina bifida. The invention further relates to screening, particularly using high-throughput screens and transgenic animal models, for compounds that modulate the activity of PAMP and presenilins. Such compounds, or gene therapy with PAMP, can be used in treating neurodegenerative diseases, particularly Alzheimer's Disease. In addition, the invention provides PAMP mutants, nucleic acids encoding for PAMP mutants, and transgenic animals expressing PAMP mutants, which in a preferred aspect result in biochemical changes similar to those induced by mutations in beta APP, PS1, or PS2 associated with familial Alzheimer's Disease.
IPC 1-7
C12N 15/12; C07K 14/705; A01K 67/027; C12N 5/10; C12Q 1/68; G01N 33/50
IPC 8 full level
C07K 14/705 (2006.01); C12N 15/12 (2006.01)
CPC (source: EP)
C07K 14/705 (2013.01); A01K 2217/05 (2013.01)
Citation (search report)
See references of WO 0060069A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0060069 A1 20001012; AU 3650600 A 20001023; EP 1165779 A1 20020102
DOCDB simple family (application)
CA 0000354 W 20000403; AU 3650600 A 20000403; EP 00915062 A 20000403