EP 1165787 A2 20020102 - ISOLATED DNA ENCODING CULLIN REGULATORS ROC1 AND ROC2, ISOLATED PROTEINS ENCODED BY THE SAME, AND METHODS UTILIZING THE SAME
Title (en)
ISOLATED DNA ENCODING CULLIN REGULATORS ROC1 AND ROC2, ISOLATED PROTEINS ENCODED BY THE SAME, AND METHODS UTILIZING THE SAME
Title (de)
CULLIN REGULATOREN ROC1 UND ROC2, DAFÜR KODIERENDE DNA, UND METHODEN ZUR IHRER VERWENDUG
Title (fr)
ADN ISOLE CODANT POUR DES REGULATEURS CULLIN ROC1 ET ROC2, PROTEINES ISOLEES CODEES PAR LEDIT ADN. PROCEDES D'UTILISATION ASSOCIES
Publication
Application
Priority
- US 0008592 W 20000331
- US 12726199 P 19990331
- US 16692799 P 19991122
Abstract (en)
[origin: WO0058472A2] The present invention provides isolated polynucleotide sequences encoding the proteins ROC1 and ROC2 and host cells comprising the same. Methods of producing the ROC1 and ROC2 proteins are also disclosed, and methods of detecting the polynucleotides in samples are included in this invention, as are antibodies to the ROC1 and ROC2 proteins and antisense molecules complementary to polynucleotides encoding the same. The present invention further includes methods for screening bioactive agents that are capable of binding to an ROC protein, methods of screening bioactive agents capable of interfering with the binding of ROC proteins, and methods of screening bioactive agents capable of modulating the activity of an ROC protein. Pharmaceutical formulations comprising such pharmacologically active compounds and methods of administering the same are an additional aspect of this invention.
IPC 1-7
C12N 15/12; C12N 15/11; C12Q 1/02; C12Q 1/68; C07K 16/18; G01N 33/68
IPC 8 full level
G01N 33/50 (2006.01); A61K 45/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP)
A61P 43/00 (2017.12); C07K 14/4702 (2013.01)
Citation (search report)
See references of WO 0058472A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0058472 A2 20001005; WO 0058472 A3 20010125; WO 0058472 A8 20010621; WO 0058472 A9 20020711; AU 4056900 A 20001016; AU 779562 B2 20050127; CA 2364305 A1 20001005; EP 1165787 A2 20020102; EP 1988165 A1 20081105; JP 2002539833 A 20021126
DOCDB simple family (application)
US 0008592 W 20000331; AU 4056900 A 20000331; CA 2364305 A 20000331; EP 00919964 A 20000331; EP 07023230 A 20000331; JP 2000608753 A 20000331