EP 1165808 A2 20020102 - DNA BINDING COMPOUND-MEDIATED MOLECULAR SWITCH SYSTEM
Title (en)
DNA BINDING COMPOUND-MEDIATED MOLECULAR SWITCH SYSTEM
Title (de)
DURCH DNS-BINDENDE VERBINDUNGEN REGULIERTER MOLEKULARER SCHALTER
Title (fr)
SYTEME DE SEQUENCE ACTIVATRICE A MEDIATION ASSUREE PAR COMPOSE DE LIAISON A L'ADN
Publication
Application
Priority
- US 0005728 W 20000303
- US 12251399 P 19990303
- US 15460599 P 19990917
Abstract (en)
[origin: WO0052179A2] The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP)
C07K 14/4738 (2013.01); C12N 15/85 (2013.01); C07K 2319/71 (2013.01); C12N 2800/40 (2013.01); C12N 2830/00 (2013.01); C12N 2830/15 (2013.01); C12N 2830/55 (2013.01); C12N 2830/60 (2013.01); C12N 2830/75 (2013.01); C12N 2830/85 (2013.01)
Citation (search report)
See references of WO 0052179A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0052179 A2 20000908; WO 0052179 A3 20001221; AU 3513000 A 20000921; CA 2367037 A1 20000908; EP 1165808 A2 20020102
DOCDB simple family (application)
US 0005728 W 20000303; AU 3513000 A 20000303; CA 2367037 A 20000303; EP 00913742 A 20000303