EP 1165819 A2 20020102 - DELIVERY OF FUNCTIONAL PROTEIN SEQUENCES BY TRANSLOCATING POLYPEPTIDES
Title (en)
DELIVERY OF FUNCTIONAL PROTEIN SEQUENCES BY TRANSLOCATING POLYPEPTIDES
Title (de)
VERABREICHUNG VON FUNKTIONELLEN PROTEINSEQUENZEN DURCH VERWENDUNG VON TRANSLOKATIERENDEN POLYPEPTIDEN
Title (fr)
DIFFUSION DE SEQUENCES DE PROTEINES FONCTIONNELLES PAR TRANSLOCATION DE POLYPEPTIDES
Publication
Application
Priority
- US 0008571 W 20000331
- US 12746799 P 19990331
Abstract (en)
[origin: WO0058488A2] The invention provides methods for modulating a cellular process by contacting a cell in culture with a cell process-modifying molecule attached to a translocating polypeptide. For example, in one embodiment, a cell in culture is transfected with a target gene by contacting the cell in culture with a polynucleotide (that contains the target gene) attached to a translocating polypeptide. In another embodiment, expression of a target gene product in a cell in culture that contains a target gene under control of one or more regulatory elements is modulated by contacting the cell in culture with one or more regulatory agents attached to a translocating polypeptide. The one or more regulatory agents are translocated into the cell in culture and interact therein with the one or more regulatory elements to modulate expression of the target gene product by the cell.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07K 14/035 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C12N 15/10 (2006.01); C12N 15/85 (2006.01); C12N 15/87 (2006.01)
CPC (source: EP)
A61K 47/62 (2017.07); A61K 48/0025 (2013.01); C07K 14/005 (2013.01); C12N 15/1055 (2013.01); C12N 15/85 (2013.01); C12N 15/87 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2710/16622 (2013.01); C12N 2800/108 (2013.01); C12N 2800/30 (2013.01); C12N 2840/20 (2013.01)
Citation (search report)
See references of WO 0058488A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0058488 A2 20001005; WO 0058488 A3 20010118; AU 2004220829 A1 20041118; AU 4055500 A 20001016; AU 775001 B2 20040715; CA 2368998 A1 20001005; EP 1165819 A2 20020102; JP 2002539839 A 20021126; JP 2005323619 A 20051124
DOCDB simple family (application)
US 0008571 W 20000331; AU 2004220829 A 20041015; AU 4055500 A 20000331; CA 2368998 A 20000331; EP 00919948 A 20000331; JP 2000608767 A 20000331; JP 2005233563 A 20050811