EP 1166102 A1 20020102 - HEART ABNORMALITIES IN VASCULAR ENDOTHELIAL GROWTH FACTOR B (VEGF-B) DEFICIENT ANIMALS AND METHODS RELATING TO THESE HEART ABNORMALITIES

Title (en)

HEART ABNORMALITIES IN VASCULAR ENDOTHELIAL GROWTH FACTOR B (VEGF-B) DEFICIENT ANIMALS AND METHODS RELATING TO THESE HEART ABNORMALITIES

Title (de)

HERZFEHLER VON VEGF-DEFIZIENTEN TIEREN UND ENTSPRECHENDE VERFAHREN

Title (fr)

ANOMALIES CARDIAQUES CHEZ LES ANIMAUX CARENCES EN FACTEUR DE CROISSANCE VASCULAIRE ENDOTHELIALE B (VEGF-B) ET METHODES RELATIVES A CES ANORMALITES CARDIAQUES

Publication

EP 1166102 A1 20020102 (EN)

Application

EP 00914803 A 20000303

Priority

US 0005465 W 20000303
US 16008399 P 19990303

Abstract (en)

[origin: WO0052462A1] VEGF-B deficient animals show heart abnormalities that appear to be caused by atrioventricular (AV) conduction defects and ischemia of the myocardium. Methods are provided for screening a compound for atrioventricular conduction or ischemia modulating activity using a VEGF-B deficient non-human animal, for the treatment or alleviation of atrioventricular conduction defects or ischemia and for diagnosing heart diseases.

IPC 1-7

G01N 33/00; A01N 43/04; A61K 38/00; A61K 39/395; A61K 39/40; A61K 39/42; A61K 39/44; C07H 21/02; C07H 21/04; C12N 15/00; C12N 15/09; C12P 19/34

IPC 8 full level

A01K 67/027 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); C07K 14/52 (2006.01); C12N 15/85 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/531 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01)

CPC (source: EP)

A01K 67/0271 (2013.01); A01K 67/0276 (2013.01); A61P 9/00 (2017.12); C07K 14/52 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0375 (2013.01); A61K 38/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0052462 A1 20000908; AU 3614700 A 20000921; CA 2363488 A1 20000908; CN 1342264 A 20020327; EP 1166102 A1 20020102; EP 1166102 A4 20020821; JP 2004513328 A 20040430; NZ 513780 A 20010928

DOCDB simple family (application)

US 0005465 W 20000303; AU 3614700 A 20000303; CA 2363488 A 20000303; CN 00804556 A 20000303; EP 00914803 A 20000303; JP 2000602624 A 20000303; NZ 51378000 A 20000303