EP 1169033 A2 20020109 - ENHANCED TISSUE AND SUBCELLULAR DELIVERY OF VITAMIN E COMPOUNDS
Title (en)
ENHANCED TISSUE AND SUBCELLULAR DELIVERY OF VITAMIN E COMPOUNDS
Title (de)
VERBESSERTE GEWEBE- UND SUBZELLULARE VERABREICHGUNG VON VITAMIN-E VERBINDUNGEN
Title (fr)
ADMINISTRATION AMELIOREE DE COMPOSES DE VITAMINE E AU NIVEAU TISSULAIRE ET INFRACELLULAIRE
Publication
Application
Priority
- US 0008524 W 20000331
- US 12759399 P 19990402
Abstract (en)
[origin: WO0059488A2] The present invention provides a method for enhancing the delivery of antioxidant Vitamin E compounds to tissues, cells and subcellular sites (both in vivo and in vitro) and in particular to mitochondria, thereby increasing the antioxidative capacity of mitochondria. The Vitamin E compounds that are administered may be cleaved by cellular esterases to release antioxidant alpha -T, beta -T, gamma -T, and/or delta -T. Further, the administration of Vitamin E compounds may have a coordinate action with respect to treating tumors in that the intact, uncleaved form of the Vitamin E compound has antitumor activity while the cleaved form exerts antioxidant effects.
IPC 1-7
IPC 8 full level
A61K 31/337 (2006.01); A61K 31/355 (2006.01); A61K 47/16 (2006.01)
CPC (source: EP)
A61K 9/0019 (2013.01); A61K 31/337 (2013.01); A61K 31/355 (2013.01); A61K 47/16 (2013.01); A61P 35/00 (2017.12); A61P 39/00 (2017.12); A61P 39/06 (2017.12)
Citation (search report)
See references of WO 0059488A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0059488 A2 20001012; WO 0059488 A3 20010301; AU 4053700 A 20001023; CA 2366884 A1 20001012; EP 1169033 A2 20020109
DOCDB simple family (application)
US 0008524 W 20000331; AU 4053700 A 20000331; CA 2366884 A 20000331; EP 00919928 A 20000331