EP 1169646 A2 20020109 - RAPID AND SENSITIVE DETECTION OF ABERRANT PROTEIN AGGREGATION IN NEURODEGENERATIVE DISEASES
Title (en)
RAPID AND SENSITIVE DETECTION OF ABERRANT PROTEIN AGGREGATION IN NEURODEGENERATIVE DISEASES
Title (de)
SCHNELLER UND EMPFINDLICHER NACHWEIS FEHLERHAFTER PROTEINAGGREGATION BEI NEURODEGENERATIVEN ERKRANKUNGEN
Title (fr)
DETECTION RAPIDE ET EFFICACE D'UNE AGREGATION DE PROTEINES ABERRANTES DANS DES MALADIES NEURODEGENERATIVES
Publication
Application
Priority
- US 0001997 W 20000125
- US 11712699 P 19990125
- US 13228899 P 19990503
- US 15593799 P 19990924
Abstract (en)
[origin: WO0043791A2] Methods, assays, and components are described in which biological samples can be rapidly and sensitively analyzed for the presence of species associated with neurodegenerative disease. Techniques and components are provided for diagnosis of disease, as well as for screening of candidate drugs for treatment of neurodegenerative disease. The techniques are simple, extremely sensitive, and utilize readily-available components. Binding species, capable of binding a neurodegenerative disease aggregate-forming or fibril-forming species, are fastened to surfaces of electrodes and surfaces of particles, or provided free in solution, to bind fibril-forming species and/or be involved in aggregation.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C07K 17/14 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
B82Y 15/00 (2013.01); B82Y 30/00 (2013.01); G01N 33/6896 (2013.01); G01N 2800/28 (2013.01)
Citation (search report)
See references of WO 0043791A2
Citation (examination)
- WO 9829727 A2 19980709 - STEPHON ROBERT L [US]
- US 5705402 A 19980106 - LELAND JONATHAN K [US], et al
- WO 9812539 A1 19980326 - MESO SCALE TECHNOLOGIES LLC [US]
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0043791 A2 20000727; WO 0043791 A3 20010726; WO 0043791 A9 20020328; AU 3474100 A 20000807; CA 2361013 A1 20000727; EP 1169646 A2 20020109; JP 2002540383 A 20021126; JP 2012230124 A 20121122; JP 5122705 B2 20130116
DOCDB simple family (application)
US 0001997 W 20000125; AU 3474100 A 20000125; CA 2361013 A 20000125; EP 00913266 A 20000125; JP 2000595161 A 20000125; JP 2012161791 A 20120720