EP 1171623 A2 20020116 - PRODUCTION OF ATTENUATED NEGATIVE STRANDED RNA VIRUS VACCINES
Title (en)
PRODUCTION OF ATTENUATED NEGATIVE STRANDED RNA VIRUS VACCINES
Title (de)
HERSTELLUNG VON ABGESCHWÄCHTEN MINUSSTRÄNGIGEN VIRALEN IMPFSTOFFEN
Title (fr)
ELABORATION DE VACCINS DE VIRUS A ARN NEGATIF SOUS FORME ATTENUEE A PARTIR DE SEQUENCES NUCLEOTIDIQUES CLONEES
Publication
Application
Priority
- US 0009695 W 20000412
- US 12900699 P 19990413
Abstract (en)
[origin: WO0061737A2] Attenuated, recombinant negative stranded RNA viruses suitable for vaccine use are produced from one or more isolated polynucleotide molecules encoding the virus. A recombinant genome or antigenome of the subject virus is modified to encode a mutation within a recombinant protein of the virus at one or more amino acid positions(s) corresponding to a site of an attenuating mutation in a heterologous, mutant negative stranded RNA virus. A similar attenuating mutation as identified in the heterologous negative stranded RNA virus is thus incorporated at a corresponding site within the recombinant virus to confer an attenuated phenotype on the recombinant virus. The attenuating mutation incorporated in the recombinant virus may be identical or conservative in relation to the attenuating mutation identified in the heterologous, mutant virus. By the transfer of mutations into recombinant negative stranded RNA viruses in this manner, candidate vaccine viruses are engineered to elicit a desired immune response against a subject virus in a host susceptible to infection thereby.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/155 (2006.01); A61P 31/14 (2006.01); C07K 14/115 (2006.01); C07K 14/135 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/00 (2006.01); C12R 1/93 (2006.01)
CPC (source: EP KR)
A61P 31/14 (2017.12 - EP); C07K 14/005 (2013.01 - EP); C12N 7/00 (2013.01 - EP); C12N 15/00 (2013.01 - KR); A61K 2039/5254 (2013.01 - EP); C12N 2760/18622 (2013.01 - EP); C12N 2760/18643 (2013.01 - EP); C12N 2760/18661 (2013.01 - EP); C12N 2760/18822 (2013.01 - EP)
Citation (search report)
See references of WO 0061737A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0061737 A2 20001019; WO 0061737 A3 20010823; AU 2005203596 A1 20050908; AU 2005203596 B2 20080911; AU 2005203596 B8 20091210; AU 2005203596 C1 20091210; AU 4231500 A 20001114; AU 781238 B2 20050512; BR 0011159 A 20020723; CA 2369817 A1 20001019; CN 1347458 A 20020501; EP 1171623 A2 20020116; IL 145797 A0 20020725; JP 2002541798 A 20021210; JP 4646410 B2 20110309; KR 100760328 B1 20071004; KR 20020008831 A 20020131; MX PA01010392 A 20030915
DOCDB simple family (application)
US 0009695 W 20000412; AU 2005203596 A 20050812; AU 4231500 A 20000412; BR 0011159 A 20000412; CA 2369817 A 20000412; CN 00806224 A 20000412; EP 00922075 A 20000412; IL 14579700 A 20000412; JP 2000611661 A 20000412; KR 20017013102 A 20011013; MX PA01010392 A 20000412