EP 1173397 A1 20020123 - STEREOSPECIFIC METHOD FOR PREPARING 4-HYDOXYALK-1-ENE COMPOUNDS
Title (en)
STEREOSPECIFIC METHOD FOR PREPARING 4-HYDOXYALK-1-ENE COMPOUNDS
Title (de)
STEREOSPEZIFISCHE HERSTELLUNG VON 4-HYDROXY-1-ALKENEN
Title (fr)
PREPARATION STEREOSPECIFIQUE DE COMPOSES 4-HYDROXYALC-1-ENE
Publication
Application
Priority
- FR 0001167 W 20000428
- FR 9905469 A 19990429
Abstract (en)
[origin: WO0066519A1] The invention concerns a method for stereospecific preparation of 4-hydroxyalk-1-ene compounds of configuration (R) or (S) of general formula (I) wherein: X represents an oxygen atom, and in such case R is selected among an alkyl, aryl, trityl, SiR, [Si(Alkyl)3; Si(Alkyl)2Ph], cyclic ether, tetrahydrofuryl group, or a group of formula -CO-R'', wherein R'' represents an alkyl group or an aryl group; R' represents the lone pair of oxygen; and n is a whole number not less than 1; or X represents a nitrogen atom, and in such case, R is selected among a hydrogen atom, an alkyl, aryl group; R' is selected among the groups of formulae -CO2R'', -SO2R'', -COR'', wherein R'' represents a alkyl group, an aryl group, or a -CF2 group, and n is a whole number not less than 1; by enantioselective allylic rearrangement reaction of aldehydes of formula (II) wherein X, R, R' and n are as defined in formula (I).
IPC 1-7
IPC 8 full level
C07B 53/00 (2006.01); C07C 41/30 (2006.01); C07C 43/178 (2006.01); C07C 231/18 (2006.01); C07F 7/10 (2006.01)
CPC (source: EP)
C07B 53/00 (2013.01); C07C 41/30 (2013.01); C07C 231/18 (2013.01); C07F 7/10 (2013.01); C07B 2200/07 (2013.01)
Citation (search report)
See references of WO 0066519A1
Designated contracting state (EPC)
CH DE GB IT LI
DOCDB simple family (publication)
WO 0066519 A1 20001109; AU 4574000 A 20001117; EP 1173397 A1 20020123; FR 2793488 A1 20001117; FR 2793488 B1 20010824; JP 2002543167 A 20021217
DOCDB simple family (application)
FR 0001167 W 20000428; AU 4574000 A 20000428; EP 00927309 A 20000428; FR 9905469 A 19990429; JP 2000615354 A 20000428