EP 1173429 A1 20020123 - PROTEASE INHIBITORS
Title (en)
PROTEASE INHIBITORS
Title (de)
PROTEASEINHIBITOREN
Title (fr)
INHIBITEURS DE PROTEASE
Publication
Application
Priority
- US 0008833 W 20000331
- US 12725099 P 19990331
Abstract (en)
[origin: WO0058296A1] The present invention provides 4-amino-4,5-dihydro-benzo[b][1,4] dioxocin-3-one protease inhibitors, and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
IPC 1-7
IPC 8 full level
A61K 31/357 (2006.01); A61K 31/381 (2006.01); A61K 31/4709 (2006.01); A61K 31/5377 (2006.01); A61P 1/02 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 321/12 (2006.01); C07D 405/12 (2006.01); C07D 407/12 (2006.01); C07D 409/12 (2006.01); C12N 9/99 (2006.01)
CPC (source: EP)
A61P 1/02 (2017.12); A61P 19/02 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07D 321/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0058296 A1 20001005; AU 4066900 A 20001016; CO 5180536 A1 20020730; EP 1173429 A1 20020123; EP 1173429 A4 20020619; HK 1044758 A1 20021101; JP 2002540199 A 20021126; PE 20001607 A1 20010307; UY 26088 A1 20001031
DOCDB simple family (application)
US 0008833 W 20000331; AU 4066900 A 20000331; CO 00023372 A 20000331; EP 00920078 A 20000331; HK 02104641 A 20020621; JP 2000607999 A 20000331; PE 0002832000 A 20000331; UY 26088 A 20000329