EP 1173443 A1 20020123 - CYCLIC UREA AND CYCLIC AMIDE DERIVATIVES
Title (en)
CYCLIC UREA AND CYCLIC AMIDE DERIVATIVES
Title (de)
CYCLISCHE HARNSTOFF UND AMIDODERIVATE
Title (fr)
DERIVES D'UREE ET D'AMIDE CYCLIQUES
Publication
Application
Priority
- US 0011836 W 20000501
- US 18303799 P 19990504
- US 55235600 A 20000419
Abstract (en)
[origin: CA2371642A1] This invention provides compounds of formula (I) wherein: A, B and D are N o r CH, with the proviso that A, B and D can not all be CH; R1 and R2 are independent substituents selected from H, CORA, NRBCORA, or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or groups; or R1 and R2 are fused to form an optionally substituted 3 to 8 membered spirocyclic alky l, alkenyl or heterocyclic ring; RA is H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl; RB is H, C1 to C3 alkyl, or substituted C1 to C3 alky l; R3 is H, OH, NH2, or optionally substituted alkyl, or alkenyl, or CORC; Rc i s H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl; R4 is a substituted benzene ring or a five or six membered ring with 1, 2 or 3 heteroatoms from the group including O, S, SO, SO2 or NR5; RF is H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl; RG is H, alkyl, o r substituted alkyl; R5 is H or alkyl; Q is O, S, NR6, or CR7R8; R6 is CN, SO2CF3, or optionally substituted alkyl, cycloalkyl, aryl, or heterocyclic ring; R7 and R8 are H, NO2, CN CO2R9, or optionally substituted alkyl, cycloalkyl, aryl, or heterocyclic; R9 is C1 to C3 alkyl; or CR7R8 form a six membered ring of structure (a): W is O or a chemical bond; or a pharmaceutically acceptable salt thereof, as well as their use and pharmaceutical compositions as agonists and antagonists of the progesterone receptor.
IPC 1-7
IPC 8 full level
A61K 31/5365 (2006.01); A61P 1/00 (2006.01); A61P 5/00 (2006.01); A61P 5/24 (2006.01); A61P 5/34 (2006.01); A61P 5/36 (2006.01); A61P 13/08 (2006.01); A61P 15/00 (2006.01); A61P 15/08 (2006.01); A61P 15/16 (2006.01); A61P 15/18 (2006.01); A61P 35/00 (2006.01); C07D 498/04 (2006.01)
CPC (source: EP)
C07D 498/04 (2013.01)
Citation (search report)
See references of WO 0066592A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 4689600 A 20001117; CA 2371642 A1 20001109; EP 1173443 A1 20020123; JP 2002543206 A 20021217; MX PA01011291 A 20030714
DOCDB simple family (application)
AU 4689600 A 20000501; CA 2371642 A 20000501; EP 00928699 A 20000501; JP 2000615622 A 20000501; MX PA01011291 A 20000501