EP 1173454 A1 20020123 - METHOD FOR PRODUCING GLYCO-CONJUGATES OF 20(S)-CAMPTOTHECIN
Title (en)
METHOD FOR PRODUCING GLYCO-CONJUGATES OF 20(S)-CAMPTOTHECIN
Title (de)
VERFAHREN ZUR HERSTELLUNG VON GLYCOKONJUGATEN VON 20(S)-CAMPTOTHECIN
Title (fr)
PROCEDE DE PRODUCTION DE GLYCOCONJUGUES DE 20(S)-CAMPTOTHECINE
Publication
Application
Priority
- DE 19909979 A 19990306
- EP 0001480 W 20000223
Abstract (en)
[origin: DE19909979A1] The invention relates to a method for producing glyco-conjugates of 20(S)-camptothecin in which a 3-O-methylated beta -L-fucose building block is linked to the 20 hydroxyl group of a camptothecin derivative via thiourea-modified peptide spacers, whereby the decisive step exists in the linking of the building block (II) with the building block (V) in the presence of a particular coupling reagent such as N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-m ethylmethane-aminium hexafluorophosphate-N-oxide (HATU).
IPC 1-7
IPC 8 full level
C07H 15/26 (2006.01); A61K 31/706 (2006.01); C07B 53/00 (2006.01); C07D 491/22 (2006.01); C07H 15/203 (2006.01); C07K 5/062 (2006.01); C07K 9/00 (2006.01)
CPC (source: EP)
C07B 53/00 (2013.01); C07D 491/22 (2013.01); C07H 1/00 (2013.01); C07H 15/26 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
See references of WO 0053614A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
DE 19909979 A1 20000907; AU 3159500 A 20000928; CA 2366632 A1 20000914; EP 1173454 A1 20020123; JP 2002539132 A 20021119; WO 0053614 A1 20000914; WO 0053614 A8 20020124
DOCDB simple family (application)
DE 19909979 A 19990306; AU 3159500 A 20000223; CA 2366632 A 20000223; EP 0001480 W 20000223; EP 00909241 A 20000223; JP 2000604049 A 20000223