EP 1173609 A2 20020123 - GENETIC ANALYSIS
Title (en)
GENETIC ANALYSIS
Title (de)
GENETISCHE ANALYSE
Title (fr)
ANALYSE GENETIQUE
Publication
Application
Priority
- EP 00909502 A 20000310
- EP 99301933 A 19990312
- GB 0000916 W 20000310
Abstract (en)
[origin: WO0055364A2] A method is described for use in whole genome analysis. The method - termed inter-population perfectly matched duplex depletion - can overcome many of the limitations of current approaches based upon SNPs and linkage disequilibrium within isolated populations. Inter-population perfectly matched duplex depletion isolates a fragment (or fragments) containing differences between the "affected" and "unaffected" populations or cells. A convenient method - terminal restriction site profiling arrays (TRSPAs) - is described for the analysis of such fragments. A totally diagnostic internal control DNA is also described which allows both the extent and exact nature of any partial digestion to be unambiguously determined for inter-population perfectly matched duplex depletion or TRSPA restriction.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12Q 1/68 (2006.01); C12Q 1/683 (2018.01); C12Q 1/6837 (2018.01); G01N 1/28 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 37/00 (2006.01)
CPC (source: EP)
C12Q 1/683 (2013.01); C12Q 1/6837 (2013.01)
Citation (search report)
See references of WO 0055364A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0055364 A2 20000921; WO 0055364 A3 20011011; AU 3178200 A 20001004; CA 2362771 A1 20000921; EP 1173609 A2 20020123; JP 2002538837 A 20021119
DOCDB simple family (application)
GB 0000916 W 20000310; AU 3178200 A 20000310; CA 2362771 A 20000310; EP 00909502 A 20000310; JP 2000605780 A 20000310