Title (en)

(Poly)peptides for the preparation of vaccines against Bordetella pertussis and/or Bordetella parapertussis, vaccines based upon such (poly)peptides, and antibodies against such peptides

Title (de)

(Poly)peptides welche zur Zubereitung von Impfstoffe gegen Bordetella pertussis und/oder Bordetella parapertussis dienen, Impfstoffe auf der Basis dieser (Poly)peptide, und Antikörper gegen dieser (Poly)peptide

Title (fr)

(Poly)peptides utiles dans la préparation des vaccins contre Bordetella pertussis et/ou Bordetella parapertussis, vaccins à base de ces (poly)peptides, et anticorps contre ces (poly)peptides

Publication

EP 1174505 A1 20020123 (EN)

Application

EP 00202309 A 20000630

Priority

EP 00202309 A 20000630

Abstract (en)

The invention relates to a peptide comprising: a) between 6 and 40 contiguous amino acid residues from the amino acid sequence of "region 1" of a Bordetella pertussis pertactin; and b) a total of between 6 and 100, preferably between 6 and 50 amino acid residues; or an analog of such a peptide; optionally in the form of a salt acceptable for pharmaceutical and/or veterinary purposes. The invention also relates to a polypeptide having the amino acid sequence of a pertactin from which, compared to the sequence of said pertactin: a) the amino acid residues that form the so-called "region 1" have been at least partly, and preferably essentially completely removed; and/or from which, b) the amino acid residues that form the so-called "region 2" have been at least partly, and preferably essentially completely removed. The invention further relates to a pharmaceutical composition, and in particular a vaccine against (at least) Bordetella pertussis and/or Bordetella parapertussis, comprising the peptide and/or the polypeptide mentioned above. Also, the invention comprises an antibody, generated/elicited against such a peptide and/or polypeptide, and to a pharmaceutical and/or veterinary composition comprising such an antibody.

IPC 1-7

C12N 15/31; C07K 14/235; C07K 16/12; A61K 38/00; A61K 39/00; C12N 15/62; A61P 31/04

IPC 8 full level

C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/002 (2006.01); A61K 39/10 (2006.01); A61K 39/395 (2006.01); A61P 31/04 (2006.01); A61P 37/02 (2006.01); C07K 14/235 (2006.01); C07K 14/325 (2006.01); C07K 16/12 (2006.01); C12N 15/00 (2006.01); C12N 15/31 (2006.01); C12N 15/62 (2006.01)

CPC (source: EP KR US)

A61P 31/04 (2018.01 - EP); A61P 37/02 (2018.01 - EP); C07K 14/235 (2013.01 - EP KR US); A61K 38/00 (2013.01 - EP US); A61K 39/00 (2013.01 - EP KR US); C07K 2319/00 (2013.01 - EP US)

Citation (search report)

• [A] WO 9115571 A1 19911017 - WELLCOME FOUND [GB]
• [Y] BOURSAUX-EUDE C ET AL: "Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 17, no. 20-21, 4 June 1999 (1999-06-04), pages 2651 - 2660, XP004169678, ISSN: 0264-410X
• [DY] MOOI F R ET AL: "POLYMORPHISM IN THE BORDETELLA PERTUSSI VIRULENCE FACTORS: P69/PERTACTIN AND PERTUSSIS TOXIN IN THE NETHERLANDS: TEMPORAL TRENDS AND EVIDENCE FOR VACCINE-DRIVEN EVOLUTION", INFECTION AND IMMUNITY,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON,US, vol. 66, no. 2, February 1998 (1998-02-01), pages 670 - 675, XP000971410, ISSN: 0019-9567
• [DY] I.G. CHARLES ET AL.: "Identification and characterization of a protective immunodominant B cell epitope of pertactin (P.69) from Bordetella pertussis.", EUR. J. IMMUNOL., vol. 21, 1991, pages 1147 - 1153, XP000974947
• [DY] MASTRANTONIO P ET AL: "ANTIGENIC VARIANTS IN BORDETELLA PERTUSSIS STRAINS ISOLATED FROM VACCINATED AND UNVACCINATED CHILDREN", MICROBIOLOGY,SOCIETY FOR GENERAL MICROBIOLOGY, READING,GB, vol. 145, no. 8, 1999, pages 2069 - 2075, XP000974981, ISSN: 1350-0872
• [Y] LI L J ET AL: "P.70 PERTACTIN, AN OUTER-MEMBRANE PROTEIN FROM BORDETELLA PARAPERTUSSIS: CLONING, NUCLEOTIDE SEQUENCE AND SURFACE EXPRESSION IN ESCHERICHIA COLI", MOLECULAR MICROBIOLOGY,GB,BLACKWELL SCIENTIFIC, OXFORD, vol. 5, no. 2, 1991, pages 409 - 417, XP000283120, ISSN: 0950-382X
• [Y] LI J ET AL: "CLONING, NUCLEOTIDE SEQUENCE AND HETEROLOGOUS EXPRESSION OF THE PROTECTIVE OUTER-MEMBRANE PROTEIN P.68 PERTACTIN FROM BORDETELLA BRONCHISEPTICA", JOURNAL OF GENERAL MICROBIOLOGY,SOCIETY FOR MICROBIOLOGY, READING,GB, vol. 138, 1992, pages 1697 - 1705, XP000974978, ISSN: 0022-1287
• [DA] CHARLES I G ET AL: "MOLECULAR CLONING AND CHARACTERIZATION OF PROTECTIVE OUTER MEMBRANE PROTEIN P.69 FROM BORDETELLA PERTUSSIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 86, no. 10, 1 May 1989 (1989-05-01), pages 3554 - 3558, XP000026467, ISSN: 0027-8424
• [A] KHELEF N ET AL: "BORDETELLA PERTUSSI AND BORDETELLA PARAPERTUSSIS: TWO IMMUNOLOGICALLY DISTINCT SPECIES", INFECTION AND IMMUNITY,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON,US, vol. 61, no. 2, February 1993 (1993-02-01), pages 486 - 490, XP000971413, ISSN: 0019-9567
• [T] BOURSAUX-EUDE C ET AL: "POLYMORPHISM OF REPEATED REGIONS OF PERTACTIN IN BORDETELLA PERTUSSIS, BORDETELLA PARAPERTUSSIS, AND BORDETELLA BRONCHISEPTICA", INFECTION AND IMMUNITY,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON,US, vol. 68, no. 8, August 2000 (2000-08-01), pages 4815 - 4817, XP000971415, ISSN: 0019-9567

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

EP 1174505 A1 20020123; AU 2001271124 B2 20061123; AU 7112401 A 20020108; BR 0112141 A 20030506; CA 2415238 A1 20020103; EP 1294890 A2 20030326; JP 2004501933 A 20040122; KR 20030032976 A 20030426; MX PA02012664 A 20040514; NZ 523354 A 20050729; US 2003187221 A1 20031002; WO 0200695 A2 20020103; WO 0200695 A3 20020808

DOCDB simple family (application)

EP 00202309 A 20000630; AU 2001271124 A 20010629; AU 7112401 A 20010629; BR 0112141 A 20010629; CA 2415238 A 20010629; EP 01950093 A 20010629; JP 2002505817 A 20010629; KR 20027018002 A 20021230; MX PA02012664 A 20010629; NL 0100493 W 20010629; NZ 52335401 A 20010629; US 31273203 A 20030410