EP 1175223 A2 20020130 - METHODS AND COMPOSITIONS FOR MODULATING AN IMMUNE RESPONSE
Title (en)
METHODS AND COMPOSITIONS FOR MODULATING AN IMMUNE RESPONSE
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR MODULIERUNG DER IMMUNANTWORT
Title (fr)
PROCEDES ET COMPOSITIONS DE MODULATION D'UNE REPONSE IMMUNITAIRE
Publication
Application
Priority
- US 0010340 W 20000417
- US 12977299 P 19990415
Abstract (en)
[origin: WO0063241A2] The present invention features new approaches for modulating immune responses. In particular, the invention features methods for modulating type 1 immune responses in a subject using modulators of Eta-1(early T lymphocyte activation-1)/osteopontin. Examplary methods feature methods of treating infections, immune disorders and diseases, autoimmune disorders and diseases, various immunodeficiencies and cancer. Also provided are biosynthetic immunomodulatory molecules that include functional domains derived from Eta-1/osteopontin. Preferred biosynthetic immunomodulatory molecules include an IL-12 stimulatory domain derived from Eta-1/osteopontin or an IL-10 inhibitory domain derived from Eta-1/osteopontin. The immunomodulatory molecules of the present invention are capable of biasing an immune response in a subject towards a type 1 immune response. Accordingly, therapeutic uses are disclosed which are based on the biosynthetic immunomodulatory molecules of the present invention.
IPC 1-7
A61K 38/17; A61K 48/00; C07K 14/47; C12N 5/10; C12N 15/12; G01N 33/50; A61P 37/02
IPC 8 full level
A61K 31/711 (2006.01); A61K 35/26 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/19 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 7/00 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 17/02 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 33/00 (2006.01); A61P 33/02 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 37/00 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); A61P 39/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/52 (2006.01); C07K 16/24 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
A61P 7/00 (2017.12); A61P 13/12 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 19/00 (2017.12); A61P 19/02 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/10 (2017.12); A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 33/00 (2017.12); A61P 33/02 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/00 (2017.12); A61P 37/02 (2017.12); A61P 37/08 (2017.12); A61P 39/00 (2017.12); A61P 43/00 (2017.12); C07K 14/52 (2013.01); C07K 16/24 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/57 (2013.01)
Citation (search report)
See references of WO 0063241A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0063241 A2 20001026; WO 0063241 A3 20010510; WO 0063241 A9 20020328; AU 4357500 A 20001102; AU 773350 B2 20040520; BR 0009791 A 20020108; CA 2370129 A1 20001026; EP 1175223 A2 20020130; IL 145891 A0 20020725; JP 2003517284 A 20030527; MX PA01010332 A 20020918
DOCDB simple family (application)
US 0010340 W 20000417; AU 4357500 A 20000417; BR 0009791 A 20000417; CA 2370129 A 20000417; EP 00923454 A 20000417; IL 14589100 A 20000417; JP 2000612329 A 20000417; MX PA01010332 A 20000417