EP 1175413 A1 20020130 - 2,1-BENZISOTHIAZOLINE 2,2-DIOXIDES
Title (en)
2,1-BENZISOTHIAZOLINE 2,2-DIOXIDES
Title (de)
2,1-BENZISOTHIAZOLIN-2,2-DIOXIDE
Title (fr)
2,1-BENZISOTHIAZOLINE 2,2-DIOXYDES
Publication
Application
Priority
- US 0011823 W 20000501
- US 18303999 P 19990504
- US 55263000 A 20000419
Abstract (en)
[origin: CA2371758A1] A progesterone receptor antagonist of formula (1) wherein R1, and R2 are eac h, independently, hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, heteroarylalkyl, and alkynyl; or R1 and R2 are taken together to form a ring and together contain -CH2(CH2)nCH2-, -CH2CH2CMe2CH2C H2- , -O(CH2)pCH2-, O(CH2)qO-, -CH2CH2OCH2CH2-, -CH2CH2NR7CH2CH2-; or R1 and R2 are a double bond, said double bond having two methyl groups bonded to the terminal end, having a cycloalkyl group bonded to the terminal end, having a n oxygen bonded to the terminal end, or having a cycloether bonded to the terminal end; R5 is a trisubstituted phenyl ring having structure (z), or R5 is a five or six membered heteroaryl ring containing 1, 2, or 3 heteroatoms selected from the group consisting of O, S, SO2 and NR6 or pharmaceutically acceptable salt thereof.
IPC 1-7
C07D 275/06; C07D 413/04; A61K 31/428; A61P 15/00; A61P 35/00
IPC 8 full level
A61K 31/428 (2006.01); A61P 13/08 (2006.01); A61P 15/00 (2006.01); A61P 15/16 (2006.01); A61P 15/18 (2006.01); A61P 35/00 (2006.01); C07D 275/06 (2006.01); C07D 413/04 (2006.01)
CPC (source: EP)
C07D 275/06 (2013.01); C07D 413/04 (2013.01)
Citation (search report)
See references of WO 0066574A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 4813800 A 20001117; CA 2371758 A1 20001109; CN 1349518 A 20020515; EP 1175413 A1 20020130; JP 2002543195 A 20021217; MX PA01011292 A 20030714
DOCDB simple family (application)
AU 4813800 A 20000501; CA 2371758 A 20000501; CN 00807091 A 20000501; EP 00930286 A 20000501; JP 2000615604 A 20000501; MX PA01011292 A 20000501