EP 1175418 A2 20020130 - THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC
Title (en)
THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC
Title (de)
THIAZOLIDINDIONDERIVAT UND SEINE VERWENDUNG ALS ANTIDIABETIKUM
Title (fr)
NOUVEL AGENT PHARMACEUTIQUE
Publication
Application
Priority
- GB 0001522 W 20000419
- GB 9909471 A 19990423
- GB 9912195 A 19990525
Abstract (en)
[origin: WO0064893A2] A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the "Polymorph") characterised in that it provides: (i) an infra red spectrum containing peaks at 1752, 1546, 1154, 621, and 602 cm<-1>; and/or (ii) a Raman spectrum containing peaks at 1751, 1243 and 602 cm<-1>; and/or (iii) a solid-state nuclear magnetic resonance spectrum containing peaks at 111.9, 114.8, 119.6, 129.2, 134.0, 138.0, 144.7, 153.2, 157.1, 170.7, 172.0 and 175.0 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings of 6.46, 5.39, 4.83, 4.68, 3.71, 3.63, 3.58, and 3.48 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.
[origin: WO0064893A2] A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-di one, maleic acid salt (the "Polymorph") characterised in that it provides: (i) an infra red spectrum containing peaks at 1752, 1546, 1154, 621, and 602 cm<-1>; and/or (ii) a Raman spectrum containing peaks at 1751, 1243 and 602 cm<-1>; and/or (iii) a solid-state nuclear magnetic resonance spectrum containing peaks at 111.9, 114.8, 119.6, 129.2, 134.0, 138.0, 144.7, 153.2, 157.1, 170.7, 172.0 and 175.0 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings of 6.46, 5.39, 4.83, 4.68, 3.71, 3.63, 3.58, and 3.48 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.
IPC 1-7
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/4439 (2006.01); A61P 3/10 (2006.01); C07D 417/00 (2006.01); C07D 417/12 (2006.01)
IPC 8 main group level
CPC (source: EP KR)
A61K 31/427 (2013.01 - KR); A61P 3/10 (2018.01 - EP); C07D 417/12 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0064893 A2 20001102; WO 0064893 A3 20010125; AP 1607 A 20060503; AP 2001002329 A0 20011231; AR 023560 A1 20020904; AR 023750 A1 20020904; AU 2755102 A 20020516; AU 4307200 A 20001110; AU 771342 B2 20040318; BG 106122 A 20020531; BG 65517 B1 20081031; BR 0009935 A 20020416; CA 2370262 A1 20001102; CN 1152878 C 20040609; CN 1355800 A 20020626; CO 5170419 A1 20020627; CZ 20013801 A3 20020717; DZ 3164 A1 20001102; EA 003031 B1 20021226; EA 200101122 A1 20020425; EG 23937 A 20080114; EP 1175418 A2 20020130; EP 1277753 A1 20030122; GC 0000250 A 20061101; HK 1045152 A1 20021115; HR P20010774 A2 20021031; HU P0200937 A2 20020828; HU P0200937 A3 20040329; IL 146115 A0 20020725; JP 2002543076 A 20021217; KR 100744361 B1 20070730; KR 20010110804 A 20011213; MA 26786 A1 20041220; MX PA01010822 A 20020604; MY 138673 A 20090731; NO 20015148 D0 20011022; NO 20015148 L 20011217; NO 320587 B1 20051227; NZ 515167 A 20040227; OA 11873 A 20060327; PE 20010045 A1 20010310; PL 351685 A1 20030602; SK 14932001 A3 20020205; TR 200103060 T2 20020521; TW I288749 B 20071021; UA 67845 C2 20040715; UY 26119 A1 20001229; YU 75401 A 20040903; ZA 200108718 B 20021203
DOCDB simple family (application)
GB 0001522 W 20000419; AP 2001002329 A 20000419; AR P000101861 A 20000419; AR P000101866 A 20000419; AU 2755102 A 20020320; AU 4307200 A 20000419; BG 10612201 A 20011120; BR 0009935 A 20000419; CA 2370262 A 20000419; CN 00809054 A 20000419; CO 00028927 A 20000419; CZ 20013801 A 20000419; DZ 003164 A 20000419; EA 200101122 A 20000419; EG 20000511 A 20000422; EP 00922793 A 20000419; EP 02080319 A 20000419; GC P2000625 A 20000423; HK 02104877 A 20020628; HR P20010774 A 20011022; HU P0200937 A 20000419; IL 14611500 A 20000419; JP 2000614245 A 20000419; KR 20017013592 A 20011023; MA 26379 A 20011022; MX PA01010822 A 20000419; MY PI20001706 A 20000421; NO 20015148 A 20011022; NZ 51516700 A 20000419; OA 1200100277 A 20000419; PE 0003632000 A 20000419; PL 35168500 A 20000419; SK 14932001 A 20000419; TR 200103060 T 20000419; TW 89107636 A 20000424; UA 2001117940 A 20000419; UY 26119 A 20000424; YU P75401 A 20000419; ZA 200108718 A 20011023