EP 1180036 A4 20020925 - CELL THERAPY FOR CHRONIC STROKE
Title (en)
CELL THERAPY FOR CHRONIC STROKE
Title (de)
ZELLTHERAPIE FÜR CHRONISCHEN SCHLAGANFALL
Title (fr)
CYTOTHERAPIE CONTRE L'ATTAQUE CHRONIQUE
Publication
Application
Priority
- US 0006912 W 20000316
- US 13123099 P 19990427
- US 14478599 P 19990720
Abstract (en)
[origin: WO0064459A1] A method of treating stroke in a patient who has undergone a stroke comprising administering at least 2 million suitable neuronal cells to at least one brain area involved in the stroke. The method comprises the step of using a twist drill or a burr to form a hole in the skull through which the cells could be administered. Exemplary cells are hNT neuronal cells, HCN-1 cells, fetal pig cells, neural crest cells, neural stem cells, or a combination thereof. Also disclosed herein is a pharmaceutical composition of 95 % pure hNT neuronal cells, which composition further includes a vial containing PBS and human neuronal cells. This vial is provided in a container with liquid nitrogen, whereby the composition is frozen and maintained at -170 DEG C before use. Also disclosed are methods of improving speech, cognitive, sensory, and motor function in a person who has experienced brain damage which interferes with function by administering a sterile composition of a sufficient number of neuronal cells or neural stem cells to the damaged area. Also disclosed is a method of replacing central nervous cells lost to neurodegenerative disease, trauma, ischemia or poisoning.
IPC 1-7
A61K 35/30; C12N 5/06; C12N 5/08; A61P 9/00; A61P 21/00; A61P 25/00
IPC 8 full level
A61K 35/30 (2015.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); C12N 5/08 (2006.01); A61K 35/12 (2015.01)
CPC (source: EP)
A61K 35/30 (2013.01); A61P 9/00 (2017.12); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61K 35/12 (2013.01)
Citation (search report)
- [XY] LAYTONBIO: "Press releases number: 24, 26, 27, 28, 29, 30, 31(j) and (k)", WWW.LAYTONBIO.COM, 9 March 1998 (1998-03-09) - 5 February 1999 (1999-02-05), XP002199748, Retrieved from the Internet <URL:http://www.laytonbio.com/whatsnew.htm>
- [Y] BONN-D: "First cell transplant aimed to reverse stroke damage", THE LANCET, vol. 352, 11 July 1998 (1998-07-11), pages 119, XP002199789
- [XY] SIMM-M: "Nachschub für die grauen Zellen", BERLINER ONLINE, 3 March 1999 (1999-03-03), XP002199747, Retrieved from the Internet <URL:http://www.BerlinOnline.de/.bin/print.php/wissen/berliner_zeitung/archiv/1999/0303/wissenschaft/0002/index.html?keywords=Nachschub%20f%FCr%20die%20grauen%20Zellen%20&ok=OK%21&match=strict&author=&ressort=Wissenschaft&von=1.2.1999&bis=1.5.1999&mark=zellen%20nachschub%20die%20grauen%20fur%20f%FCr> [retrieved on 20020521]
- [Y] FLAX-JD ET AL.: "Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes", NATURE BIOTECHNOLOGY, vol. 16, November 1998 (1998-11-01), pages 1033 - 1039, XP002199749
- See references of WO 0064459A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0064459 A1 20001102; AT E444758 T1 20091015; AU 3888900 A 20001110; AU 780365 B2 20050317; CA 2371017 A1 20001102; DE 60043102 D1 20091119; EP 1180036 A1 20020220; EP 1180036 A4 20020925; EP 1180036 B1 20091007; JP 2003521474 A 20030715
DOCDB simple family (application)
US 0006912 W 20000316; AT 00918005 T 20000316; AU 3888900 A 20000316; CA 2371017 A 20000316; DE 60043102 T 20000316; EP 00918005 A 20000316; JP 2000613449 A 20000316