Global Patent Index - EP 1180122 A4

EP 1180122 A4 20030326 - STRUCTURAL MODELS FOR CYTOPLASMIC DOMAINS OF TRANSMEMBRANE RECEPTORS

Title (en)

STRUCTURAL MODELS FOR CYTOPLASMIC DOMAINS OF TRANSMEMBRANE RECEPTORS

Title (de)

STRUKTURMODELLE FüR CYTOPLASMATISCHE DOMäNEN VON TRANSMEMBRANEN REZEPTOREN

Title (fr)

MODELES STRUCTURAUX POUR DOMAINES CYTOPLASMIQUES DE RECEPTEURS TRANSMEMBRANAIRES

Publication

EP 1180122 A4 20030326 (EN)

Application

EP 00936458 A 20000601

Priority

  • US 0015153 W 20000601
  • US 32344799 A 19990601

Abstract (en)

[origin: WO0073342A1] Polypeptides containing a series of heptad-repeats that mimic a transmembrane domain and a selected cytoplasmic domain attached to the series of heptad repeats are provided which can be used in construction of structural models for evaluating the structure and activity of occupied and clustered transmembrane proteins and identifying therapeutic compounds.

IPC 1-7

C07K 14/705; C07K 16/28; G01N 33/53

IPC 8 full level

C12N 15/09 (2006.01); A61K 45/00 (2006.01); A61P 1/04 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP)

A61P 1/04 (2017.12); A61P 9/10 (2017.12); A61P 11/06 (2017.12); A61P 17/02 (2017.12); A61P 19/02 (2017.12); A61P 25/00 (2017.12); A61P 43/00 (2017.12); C07K 14/705 (2013.01); C07K 14/70546 (2013.01); C07K 14/7055 (2013.01); C07K 16/28 (2013.01); G01N 33/68 (2013.01); G01N 2500/02 (2013.01); G01N 2500/20 (2013.01)

Citation (search report)

  • [XY] HEMLER M E ET AL: "Functional role for integrin alpha subunit cytoplasmic domains.", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 57, 1992, Meeting;Cold Spring Harbor, New York, USA; May 27-June 3, 1992, 1992 Cold Spring Harbor Laboratory Press 10 Skyline Drive, Plainview, New York 11803, USA, pages 213 - 220, XP009004544, ISSN: 0-87969-064-X
  • [XDY] MUIR TOM W ET AL: "Design and chemical synthesis of a neoprotein structural model for the cytoplasmic domain of a multisubunit cell-surface receptor: Integrin alpha-IIb-beta-3 (platelet GPIIb-IIIa)", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, PA, US, vol. 33, no. 24, 1994, pages 7701 - 7708, XP002144665, ISSN: 0006-2960
  • [Y] HUGHES PAUL E ET AL: "Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway.", CELL, vol. 88, no. 4, 1997, pages 521 - 530, XP001121118, ISSN: 0092-8674
  • [Y] THOMAS SHEILA M ET AL: "Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.", NATURE (LONDON), vol. 376, no. 6537, 1995, pages 267 - 271, XP001135012, ISSN: 0028-0836
  • [Y] ALLMAN R ET AL: "The alphavbeta3 integrin as a molecular target for anticancer drug design", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 33, September 1997 (1997-09-01), pages S173, XP004283621, ISSN: 0959-8049
  • [A] WILLIAMS MICHAEL J ET AL: "The inner world of cell adhesion: Integrin cytoplasmic domains.", TRENDS IN CELL BIOLOGY, vol. 4, no. 4, 1994, pages 109 - 112, XP009004580, ISSN: 0962-8924
  • See references of WO 0073342A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0073342 A1 20001207; AU 5177300 A 20001218; AU 765990 B2 20031009; CA 2374133 A1 20001207; EP 1180122 A1 20020220; EP 1180122 A4 20030326; JP 2003504308 A 20030204

DOCDB simple family (application)

US 0015153 W 20000601; AU 5177300 A 20000601; CA 2374133 A 20000601; EP 00936458 A 20000601; JP 2001500666 A 20000601