Global Patent Index - EP 1180140 A4

EP 1180140 A4 20040825 - VARIANTS OF TRAF2 WHICH ACT AS AN INHIBITOR OF TNF-ALPHA SIGNALING PATHWAY

Title (en)

VARIANTS OF TRAF2 WHICH ACT AS AN INHIBITOR OF TNF-ALPHA SIGNALING PATHWAY

Title (de)

TRAF2-VARIANTEN, DIE ALS INHIBITOR DES TNF-ALPHA-SIGNALWEGES AGIEREN.

Title (fr)

VARIANTES DE TRAF2 AGISSANT COMME INHIBITEURS DE LA VOIE DE SIGNALISATION TNF-ALPHA

Publication

EP 1180140 A4 20040825 (EN)

Application

EP 00920190 A 20000406

Priority

  • US 0009178 W 20000406
  • US 13194099 P 19990430

Abstract (en)

[origin: WO0066737A1] The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF alpha signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as "TRAF2 truncated" or "TRAF2TR" and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as "TRAF2 truncated-deleted" or "TRAF2TD". Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF alpha signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF alpha binding.

IPC 1-7

C12N 15/12

IPC 8 full level

A61K 38/00 (2006.01); C12N 15/09 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 1/00 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/715 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01)

CPC (source: EP KR)

A61P 1/00 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/08 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 17/02 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 14/7151 (2013.01 - EP); C12N 15/11 (2013.01 - KR); A61K 38/00 (2013.01 - EP); A61K 48/00 (2013.01 - EP); A61K 2039/53 (2013.01 - EP)

Citation (search report)

  • [A] ROTHE M ET AL: "A NOVEL FAMILY OF PUTATIVE SIGNAL TRANSDUCERS ASSOCIATED WITH THE CYTOPLASMIC DOMAIN OF THE 75 KDA TUMOR NECROSIS FACTOR RECEPTOR", CELL, MIT PRESS, CAMBRIDGE, MA,, US, vol. 78, no. 4, 26 August 1994 (1994-08-26), pages 681 - 692, XP000607783, ISSN: 0092-8674
  • [Y] HSU H ET AL: "TRADD-TRAF2 AND TRADD-FADD INTERACTIONS DEFINE TWO DISTINCT TNF RECEPTOR 1 SIGNAL TRANSDUCTION PATHWAYS", CELL, MIT PRESS, CAMBRIDGE, MA,, US, vol. 84, no. 2, 26 January 1996 (1996-01-26), pages 299 - 308, XP000607990, ISSN: 0092-8674
  • [Y] ROTHE M ET AL: "TRAF2-MEDIATED ACTIVATION OF NF-KB BY TNF RECEPTOR 2 AND CD40", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 269, no. 5229, 8 September 1995 (1995-09-08), pages 1424 - 1427, XP000608733, ISSN: 0036-8075
  • [Y] LEE SOO YOUNG ET AL: "CD30/TNF receptor-associated factor interaction: NF-kappa-B activation and binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 93, no. 18, 1996, 1996, pages 9699 - 9703, XP002278072, ISSN: 0027-8424
  • [Y] HORIE RYOUICHI ET AL: "A novel domain in the CD30 cytoplasmic tail mediates NFkB activation", INTERNATIONAL IMMUNOLOGY, vol. 10, no. 2, February 1998 (1998-02-01), pages 203 - 210, XP002278073, ISSN: 0953-8178
  • [Y] DUCKETT COLIN S ET AL: "Induction of nuclear factor kappa-B by the CD30 receptor is mediated by TRAF1 and TRAF2", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 3, 1997, pages 1535 - 1542, XP002278074, ISSN: 0270-7306
  • [Y] DADGOSTAR HAJIR ET AL: "An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kappaB activation but is dispensable for c-Jun N-terminal kinase signaling", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 38, 18 September 1998 (1998-09-18), pages 24775 - 24780, XP002278075, ISSN: 0021-9258
  • [Y] CAO Z ET AL: "TRAF6 IS A SIGNAL TRANSDUCER FOR INTERLEUKIN-1", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 383, October 1996 (1996-10-01), pages 443 - 446, XP002926064, ISSN: 0028-0836
  • See also references of WO 0066737A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0066737 A1 20001109; WO 0066737 A9 20020829; AU 2005203749 A1 20050915; AU 4076800 A 20001117; CA 2372803 A1 20001109; CN 1309830 C 20070411; CN 1353754 A 20020612; EP 1180140 A1 20020220; EP 1180140 A4 20040825; HU P0200946 A2 20020729; HU P0200946 A3 20050628; IL 146241 A0 20020725; JP 2002542826 A 20021217; KR 20020012194 A 20020215; MX PA01011107 A 20020809

DOCDB simple family (application)

US 0009178 W 20000406; AU 2005203749 A 20050817; AU 4076800 A 20000406; CA 2372803 A 20000406; CN 00808279 A 20000406; EP 00920190 A 20000406; HU P0200946 A 20000406; IL 14624100 A 20000406; JP 2000615761 A 20000406; KR 20017013914 A 20011030; MX PA01011107 A 20000406