EP 1180156 A1 20020220 - METHODS FOR INDUCTION OF TOLERANCE TO ADENOVIRAL VECTORS AND TRANSGENE PRODUCTS
Title (en)
METHODS FOR INDUCTION OF TOLERANCE TO ADENOVIRAL VECTORS AND TRANSGENE PRODUCTS
Title (de)
METHODEN ZUR INDUKTION VON TOLERANZ GEGENÜBER ADENOVIRALEN VEKTOREN UND TRANSGENEN PRODUKTEN
Title (fr)
METHODES D'INDUCTION DE TOLERANCE A DES VECTEURS ADENOVIRAUX ET A DES PRODUITS TRANSGENIQUES
Publication
Application
Priority
- US 0014344 W 20000525
- US 13627899 P 19990527
Abstract (en)
[origin: WO0073477A1] The invention relates to a method for inducing tolerance to an adenoviral vector and/or transgene product in a host, thereby allowing persistent transgene expression in the host and allowing repeated vector administration to the host while minimizing or eliminating the host immune response. The method comprises pretreating a host by administering to the host adenoviral vector-infected antigen presenting cells wherein said adenoviral vector comprises heterologous nucleic acids encoding an immunomodulatory molecule and a transgene and wherein said adenoviral vector-infected antigen presenting cells migrate to lymphoid organs and/or lymph nodes and induce tolerance. The method further provides for subsequentadministration to the host of an adenoviral vector comprising a heterologous nucleic acid encoding said transgene wherein the host immune response is reduced or eliminated to said adenoviral vector and said transgene even upon repeated administration of said adenoviral vector.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/43 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C12N 15/861 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
A61K 39/4615 (2023.05); A61K 39/4622 (2023.05); A61K 39/46434 (2023.05); A61K 39/464417 (2023.05); A61K 39/464434 (2023.05); A61K 39/46444 (2023.05); A61P 43/00 (2017.12); C12N 15/86 (2013.01); A61K 2239/31 (2023.05); C12N 2710/10343 (2013.01); C12N 2840/20 (2013.01); C12N 2840/203 (2013.01)
Citation (search report)
See references of WO 0073477A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0073477 A1 20001207; AU 5161600 A 20001218; CA 2373547 A1 20001207; EP 1180156 A1 20020220; JP 2003501040 A 20030114
DOCDB simple family (application)
US 0014344 W 20000525; AU 5161600 A 20000525; CA 2373547 A 20000525; EP 00936276 A 20000525; JP 2001500789 A 20000525