EP 1180999 A4 20050330 - RECOMBINANT VACCINE AGAINST BOTULINUM NEUROTOXIN
Title (en)
RECOMBINANT VACCINE AGAINST BOTULINUM NEUROTOXIN
Title (de)
REKOMBINANTER IMPFSTOFF GEGEN BOTULINUM-NEUROTOXIN
Title (fr)
VACCIN DE RECOMBINAISON CONTRE LA NEUROTOXINE BOTULIQUE
Publication
Application
Priority
- US 0012890 W 20000512
- US 13386699 P 19990512
- US 13387399 P 19990512
- US 13386999 P 19990512
- US 13386599 P 19990512
- US 13386899 P 19990512
- US 13386799 P 19990512
- US 14619299 P 19990729
Abstract (en)
[origin: WO0067700A2] This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as well as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/08 (2006.01); A61P 25/00 (2006.01); A61P 31/04 (2006.01); A61P 37/00 (2006.01); C07K 14/33 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01); C12R 1/84 (2006.01)
CPC (source: EP US)
A61K 39/08 (2013.01 - EP); A61P 25/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 37/00 (2018.01 - EP); C07K 14/33 (2013.01 - EP); A61K 39/00 (2013.01 - EP US); Y02A 50/30 (2018.01 - EP)
Citation (search report)
- [X] BYRNE MICHAEL P ET AL: "Purification, potency, and efficacy of the botulinum neurotoxin type A biding domain from Pichia pastoris as a recombinant vaccine candidate", INFECTION AND IMMUNITY, vol. 66, no. 10, October 1998 (1998-10-01), pages 4817 - 4822, XP002301389, ISSN: 0019-9567
- [X] CLAYTON M A ET AL: "Protective vaccination with a recombinant fragment of Clostridium botulinum neurotoxin serotype A expressed from a synthetic gene in E. coli", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 63, no. 7, July 1995 (1995-07-01), pages 2738 - 2742, XP002110803, ISSN: 0019-9567
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0067700 A2 20001116; WO 0067700 A3 20010208; AU 5003500 A 20001121; AU 783450 B2 20051027; CA 2371279 A1 20001116; EP 1180999 A2 20020227; EP 1180999 A4 20050330; JP 2004512004 A 20040422
DOCDB simple family (application)
US 0012890 W 20000512; AU 5003500 A 20000512; CA 2371279 A 20000512; EP 00932296 A 20000512; JP 2000616731 A 20000512