Global Patent Index - EP 1181308 A4

EP 1181308 A4 20041027 - METHODS FOR THE TREATMENT OF NEURONAL ATROPHY-ASSOCIATED DEMENTIA

Title (en)

METHODS FOR THE TREATMENT OF NEURONAL ATROPHY-ASSOCIATED DEMENTIA

Title (de)

METHODEN ZUR BEHANDLUNG VON NEURONALER ATROPHIE-ASSOZIIERTER DEMENZ

Title (fr)

METHODES DE TRAITEMENT DE DEMENCE NEURONALE ASSOCIEE A UNE ATROPHIE

Publication

EP 1181308 A4 20041027 (EN)

Application

EP 00928662 A 20000428

Priority

  • US 0011739 W 20000428
  • US 13189099 P 19990430
  • US 13199199 P 19990430
  • US 14064399 P 19990623
  • US 14064499 P 19990623

Abstract (en)

[origin: WO0066617A1] The invention features methods of diagnosis and treating a patient having Alzheimer's disease or other neuronal atrophy-associated dementia by determining or altering, respectively, the level of activity of pathways from the endoplasmic reticulum to lysosomes in the patient.

IPC 1-7

C07K 5/00; C07K 14/00; A61K 38/00; A61K 38/43; A61K 39/395; G01N 33/68

IPC 8 full level

A01K 67/027 (2006.01); A61K 31/198 (2006.01); A61K 31/4172 (2006.01); A61K 31/475 (2006.01); A61K 31/52 (2006.01); A61K 45/00 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 9/14 (2006.01); C12N 9/64 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/02 (2006.01); C12Q 1/34 (2006.01); C12Q 1/37 (2006.01); G01N 33/15 (2006.01); G01N 33/48 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); A61P 25/28 (2017.12); C07K 14/4711 (2013.01); C07K 14/705 (2013.01); C12N 9/14 (2013.01); C12N 9/6478 (2013.01); C12N 15/8509 (2013.01); G01N 33/6896 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0306 (2013.01); A01K 2267/0312 (2013.01); A01K 2267/0318 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); G01N 2333/916 (2013.01); G01N 2500/10 (2013.01)

Citation (search report)

  • [X] US 5686269 A 19971111 - NIXON RALPH A [US]
  • [X] WO 9744668 A1 19971127 - WOMENS & CHILDRENS HOSPITAL [AU], et al
  • [X] WO 9821589 A1 19980522 - UNIV PENNSYLVANIA [US], et al
  • [X] US 5538983 A 19960723 - BUXBAUM JOSEPH D [US], et al
  • [X] US 5028622 A 19910702 - PLAITAKIS ANDREAS [US]
  • [X] EP 0652012 A1 19950510 - NAITO ALBERT [US]
  • [X] WO 9840484 A1 19980917 - UNIV COLUMBIA [US], et al
  • [X] SOUSTEK Z: "Autolysosomes in Alzheimer's disease and their possible role in its pathogenesis. An ultrastructural study.", ZENTRALBLATT FUR PATHOLOGIE. JUL 1994, vol. 140, no. 2, July 1994 (1994-07-01), pages 143 - 148, XP008034352, ISSN: 0863-4106
  • [X] ANGLADE P ET AL: "Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.", HISTOLOGY AND HISTOPATHOLOGY. JAN 1997, vol. 12, no. 1, January 1997 (1997-01-01), pages 25 - 31, XP008034349, ISSN: 0213-3911
  • [X] BERNSTEIN H G ET AL: "Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia.", ACTA HISTOCHEMICA. SUPPLEMENTBAND. 1992, vol. 42, 1992, pages 19 - 24, XP008034353, ISSN: 0567-7556
  • [X] GUO Q ET AL: "Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.", THE JOURNAL OF NEUROSCIENCE : THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE. 1 JUN 1997, vol. 17, no. 11, 1 June 1997 (1997-06-01), pages 4212 - 4222, XP002293297, ISSN: 0270-6474
  • See references of WO 0066617A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0066617 A1 20001109; AU 4673400 A 20001117; AU 4686300 A 20001117; AU 772054 B2 20040408; AU 784048 B2 20060119; CA 2370177 A1 20001109; CA 2372190 A1 20001109; EP 1181308 A1 20020227; EP 1181308 A4 20041027; EP 1181550 A1 20020227; EP 1181550 A4 20050302; JP 2002543425 A 20021217; JP 2003514216 A 20030415; WO 0067016 A1 20001109; WO 0067016 A9 20020711

DOCDB simple family (application)

US 0011739 W 20000428; AU 4673400 A 20000428; AU 4686300 A 20000428; CA 2370177 A 20000428; CA 2372190 A 20000428; EP 00928500 A 20000428; EP 00928662 A 20000428; JP 2000615646 A 20000428; JP 2000615804 A 20000428; US 0011401 W 20000428