Title (en)

OLIGONUCLEOTIDE DERIVATIVES DIRECTED AGAINST HUMAN BCL-XL AND HUMAN BCL-2 MRNA

Title (de)

OLIGONUKLEOTIDE-DERIVATE GEGEN MENSCHLICHE BCL-XL UND MENSCHLICHE BCL-2 MRNA

Title (fr)

DERIVES D'OLIGONUCLEOTIDES DIRIGES CONTRE LES ARN MESSAGERSHUMAINS BCL-XL ET BCL-2

Publication

EP 1181361 A2 20020227 (EN)

Application

EP 00925239 A 20000426

Priority

• EP 0003708 W 20000426
• GB 9910119 A 19990430

Abstract (en)

[origin: WO0066724A2] The present invention relates to antisense oligonucleotide derivatives directed against human bcl-xL mRNA and being capable of modulating the biosynthesis of human bcl-xL protein. Furthermore, the present invention relates to antisense oligonucleotide derivatives directed against both human bcl-xL nRNA and human bcl-2 mRNA, and being capable of modulating the biosynthesis of both human bcl-xl protein and human bcl-2 protein. The present invention further relates to a pharmaceutical composition comprising such oligonucleotide derivatives, uses thereof and methods of treatment and diagnosis utilizing such oligonucleotide derivatives.

IPC 1-7

C12N 15/11; C07K 14/82; A61K 31/70; A61K 48/00; A61P 35/00

IPC 8 full level

A61P 35/00 (2006.01); C12N 15/113 (2010.01)

CPC (source: EP)

A61P 35/00 (2017.12); C12N 15/1135 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/33 (2013.01); C12N 2310/341 (2013.01); C12N 2310/346 (2013.01)

C-Set (source: EP)

C12N 2310/321 + C12N 2310/3525

Citation (search report)

See references of WO 0066724A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0066724 A2 20001109; WO 0066724 A3 20010208; AU 4402500 A 20001117; EP 1181361 A2 20020227; GB 9910119 D0 19990630

DOCDB simple family (application)

EP 0003708 W 20000426; AU 4402500 A 20000426; EP 00925239 A 20000426; GB 9910119 A 19990430