EP 1185258 A1 20020313 - THERAPEUTIC USES FOR NITRIC OXIDE INHIBITORS
Title (en)
THERAPEUTIC USES FOR NITRIC OXIDE INHIBITORS
Title (de)
THERAPEUTISCHE VERWENDUNG VON STICKSTOFFMONOXYDINHIBITOREN
Title (fr)
UTILISATIONS THERAPEUTIQUES D'INHIBITEURS D'OXYDE NITRIQUE
Publication
Application
Priority
- US 0013685 W 20000518
- US 31592999 A 19990520
Abstract (en)
[origin: WO0071112A1] Nitric oxide (NO) is an important growth regulator in an intact developing organism. The present invention relates to a method of increasing in a mammal a population of hematopoietic stem cells which are capable of undergoing normal hematopoiesis, differentiation and maturation in hematopoietic tissue, wherein the hematopoietic tissue is contacted with multiple doses of at least one inhibitor of NO, such as inhibitors of nitric oxide synthase (NOS). The present invention also relates to a method of increasing a population of cells in S phase in a tissue of a mammal, comprising contacting the tissue with multiple doses of at least one inhibitor of NO, such as an inhibitor of NOS. The invention also pertains to a method of regenerating tissue in an adult mammal comprising contacting a selected tissue (e.g., blood, skin, bone and digestive epithelium), or precursor cells, with multiple doses of at least one inhibitor of NO, thereby inhibiting differentiation and inducing proliferation of cells of the tissue.
IPC 1-7
A61K 31/131; A61K 31/155; A61K 31/198; A61K 31/223; A61P 7/00
IPC 8 full level
C12N 5/07 (2010.01); A61K 31/00 (2006.01); A61K 31/131 (2006.01); A61K 31/155 (2006.01); A61K 31/17 (2006.01); A61K 31/198 (2006.01); A61K 31/216 (2006.01); A61K 31/22 (2006.01); A61K 31/223 (2006.01); A61K 35/28 (2006.01); A61P 7/00 (2006.01); A61P 7/06 (2006.01); C12N 5/0789 (2010.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/155 (2013.01); A61K 31/17 (2013.01); A61K 31/198 (2013.01); A61K 31/216 (2013.01); A61K 31/22 (2013.01); A61K 31/223 (2013.01); A61P 7/00 (2017.12); A61P 7/06 (2017.12)
Citation (search report)
See references of WO 0071112A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0071112 A1 20001130; AU 5275200 A 20001212; CA 2374209 A1 20001130; EP 1185258 A1 20020313; JP 2003500355 A 20030107
DOCDB simple family (application)
US 0013685 W 20000518; AU 5275200 A 20000518; CA 2374209 A 20000518; EP 00937605 A 20000518; JP 2000619419 A 20000518