Global Patent Index - EP 1185622 A4

EP 1185622 A4 2002-09-18 - METHODS OF MAKING PANCREATIC ISLET CELLS

Title (en)

METHODS OF MAKING PANCREATIC ISLET CELLS

Title (de)

Verfahren zur Herstellung von pankreatischen Inselzellen

Title (fr)

FABRICATION D'ILOTS DE CELLULES PANCREATIQUES

Publication

EP 1185622 A4 (EN)

Application

EP 00941645 A

Priority

  • US 0017208 W
  • US 14063999 P

Abstract (en)

[origin: WO0078929A1] The invention features methods of promoting dedifferentiation of pancreatic cells, methods of obtaining pancreatic islet cells from the dedifferentiated pancreatic cells, and methods of treating a subject having a disorder characterized by insufficient pancreatic islet function by administering pancreatic islet cells obtained by these methods.

IPC 1-7 (main, further and additional classification)

C12N 5/00; C12N 5/02; C12N 5/06

IPC 8 full level (invention and additional information)

C12N 5/02 (2006.01); C12N 5/071 (2010.01); A61K 35/12 (2015.01)

CPC (invention and additional information)

C12N 5/0676 (2013.01); A61K 35/12 (2013.01); C12N 2500/90 (2013.01); C12N 2501/117 (2013.01); C12N 2506/22 (2013.01)

Citation (search report)

  • [A] WO 9640872 A1 19961219 - ONTOGENY INC [US], et al
  • [E] US 6326201 B1 20011204 - FUNG BRENDA [US], et al
  • [E] WO 0229010 A2 20020411 - CHRU LILLE [FR]
  • [X] GMYR V ET AL: "EXPANSION OF HUMAN DUCTAL PANCREATIC STEM CELLS OBTAINED FROM MAIN DUCT, PURIFIED ISLET PREPARATION, OR EXOCRINE TISSUE", ACTA DIABETOLOGICA, SPRINGER INTERNATIONAL, BERLIN, DE, vol. 34, no. 2, 1997, pages 107, XP001010264, ISSN: 0940-5429
  • [X] KERR-CONTE J ET AL: "Model for human islet neogenesis in vitro from adult pancreatic preparations.", TRANSPLANTATION PROCEEDINGS, vol. 27, no. 6, 1995, Fifth Congress of the International Pancreas and Islet Transplant Association: Cure of Diabetes by Transplantation;Miami Beach, Florida, USA; June 18-22, 1995, pages 3268, XP002206387, ISSN: 0041-1345
  • [Y] KERR-CONTE J ET AL: "Model for islet cell neogenesis from adult human pancreatic ductal epithelium in vitro", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES, JOHANN AMBROSIUS BARTH, DE, vol. 105, no. 4, 1997, pages A28 - A29, XP000925803, ISSN: 0947-7349
  • [Y] KERR-CONTE J ET AL: "DUCTAL CYST FORMATION IN COLLAGEN-EMBEDDED ADULT HUMAN ISLET PREPARATIONS A MEANS TO THE REPRODUCTION OF NESIDIOBLASTOSIS IN VITRO", DIABETES, NEW YORK, NY, US, vol. 45, no. 8, August 1996 (1996-08-01), pages 1108 - 1114, XP000939167, ISSN: 0012-1797
  • [Y] ROSENBERG L: "IN VIVO CELL TRANSFORMATION: NEOGENESIS OF BETA CELLS FROM PANCREATIC DUCTAL CELLS", CELL TRANSPLANTATION, ELSEVIER SCIENCE, US, vol. 4, no. 4, 1995, pages 371 - 383, XP000939136, ISSN: 0963-6897
  • [Y] WANG R N ET AL: "PANCREATIC DUCT CELLS EXPRESS GASTRIN AND TGF-ALPHA DURING DUCT TO ISLET-CELL DIFFERENTIATION IN DUCT-LIGATED ADULT RATS", DIABETOLOGIA, BERLIN, DE, vol. 39, no. SUPPL 1, 1996, pages A63, XP000925868, ISSN: 0012-186X
  • [Y] YUAN S ET AL: "TRANSDIFFERENTIATION OF HUMAN ISLETS TO PANCREATIC DUCTAL CELLS IN COLLAGEN MATRIX CULTURE", DIFFERENTIATION, SPRINGER VERLAG, DE, vol. 61, no. 1, 1996, pages 67 - 75, XP000939119, ISSN: 0301-4681
  • [A] BONNER-WEIR SUSAN ET AL: "Partial pancreatectomy as a model of pancreatic regeneration.", PANCREATIC GROWTH AND REGENERATION., 1997, S. Karger AG;S. Karger AG P.O. Box, Allschwilerstrasse 10, CH-4009 Basel, Switzerland; New York, New York, USA, pages 138 - 153, XP001083955, ISBN: 3-8055-6618-2
  • See also references of WO 0078929A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0078929 A1 20001228; AU 5632600 A 20010109; CA 2375509 A1 20001228; EP 1185622 A1 20020313; EP 1185622 A4 20020918

INPADOC legal status


2008-08-20 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20080229

2005-06-15 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050503

2004-05-26 [RBV] DESIGNATED CONTRACTING STATES (CORRECTION)

- Designated State(s): CH DE DK FR GB LI

2002-09-18 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020802

2002-09-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2002-09-11 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 12N 5/00 A, 7C 12N 5/02 B, 7C 12N 5/06 B

2002-04-10 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: BONNER-WEIR, SUSAN

2002-04-10 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: TANEJA, MONICA

2002-03-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20011220

2002-03-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2002-03-13 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI