EP 1185635 A2 20020313 - NON-HUMAN TRANSGENIC ANIMALS DEFICIENT IN GAS6 FUNCTION AND THEIR USE
Title (en)
NON-HUMAN TRANSGENIC ANIMALS DEFICIENT IN GAS6 FUNCTION AND THEIR USE
Title (de)
NICHT-MENSCHLICHE GAS6 DEFIZIENTE TRANSGENE TIERE UND IHRE VERWENDUNG
Title (fr)
ANIMAUX TRANSGENIQUES NON-HUMAINS DEFICIENTS EN FONCTION "GAS6" (GROWTH ARREST-SPECIFIC GENE 6) ET LEUR UTILISATION
Publication
Application
Priority
- EP 00935193 A 20000608
- EP 0005318 W 20000608
- EP 99201859 A 19990610
Abstract (en)
[origin: WO0076309A2] It has been shown that Gas6 deficient endothelial cells are resistant to activation by endotoxin and TNF- alpha <i>in vitro</i> and <i>in vivo</i> and that leukocytes did not or much less extravasate in Gas6 deficient mice. The present invention also relates to the manufacture of a medicament for the treatment of endothelial dysfunction. The present invention further relates to the use of an inhibitor of the Gas6 function and/or an inhibitor of a Gas6 receptor for the manufacture of said medicament.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); C12N 15/00 (2006.01); C12N 15/85 (2006.01); A61P 9/00 (2006.01); C07K 14/745 (2006.01)
CPC (source: EP)
A01K 67/0276 (2013.01); A61P 9/00 (2017.12); C12N 15/8509 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0375 (2013.01)
Citation (search report)
See references of WO 0076309A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0076309 A2 20001221; WO 0076309 A3 20010419; AU 5077100 A 20010102; EP 1185635 A2 20020313
DOCDB simple family (application)
EP 0005318 W 20000608; AU 5077100 A 20000608; EP 00935193 A 20000608