EP 1187830 A1 20020320 - PROCESS FOR THE PREPARATION OF PAROXETINE AND STRUCTURALLY RELATED COMPOUNDS
Title (en)
PROCESS FOR THE PREPARATION OF PAROXETINE AND STRUCTURALLY RELATED COMPOUNDS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON PAROXETIN UND STRUKTURELL VERWANDTER VERBINDUNGEN
Title (fr)
PROCEDE DE PREPARATION DE PAROXETINE ET COMPOSES STRUCTURELLEMENT APPARENTES
Publication
Application
Priority
- GB 0002455 W 20000622
- GB 9914583 A 19990622
Abstract (en)
[origin: WO0078753A1] The (-) trans isomer of 4-(4'-fluorophenyl)-3-(3, 4'-methylenedioxyphenoxymethyl)-piperidine(paroxetine) according to formula (1) is used in therapy as the hydrochloride salt to treat inter alia depression, obsessive compulsive disorder (OCD) and panic. There is described a process for the preparation of a compound of formula (1) or a phramaceutically acceptable salt thereof, in which R<1> is a substituted phenyl group, the process comprising hydrolysing a solution of a carbamate of formula (2) in which R<1> is as defined above and R<2> is a C1-6 alkyl group, a C3-6 cycloalkyl group, aralkyl group, phenyl or substituted phenyl group; with a base by forming a finely divided complex derived from the base and the carbamate and heating it in suspension in a solvent.
IPC 1-7
IPC 8 full level
A61K 31/443 (2006.01); A61P 3/04 (2006.01); A61P 15/00 (2006.01); A61P 17/14 (2006.01); A61P 25/00 (2006.01); A61P 25/06 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); C07D 211/22 (2006.01); C07D 405/12 (2006.01)
CPC (source: EP)
A61P 3/04 (2017.12); A61P 15/00 (2017.12); A61P 17/14 (2017.12); A61P 25/00 (2017.12); A61P 25/06 (2017.12); A61P 25/18 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 25/32 (2017.12); C07D 211/22 (2013.01); C07D 405/12 (2013.01)
Citation (search report)
See references of WO 0078753A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0078753 A1 20001228; AU 5553200 A 20010109; EP 1187830 A1 20020320; GB 9914583 D0 19990825; JP 2003502422 A 20030121
DOCDB simple family (application)
GB 0002455 W 20000622; AU 5553200 A 20000622; EP 00940621 A 20000622; GB 9914583 A 19990622; JP 2001504919 A 20000622