EP 1187924 A1 20020320 - SUBSTRATE TRAPPING PROTEIN TYROSINE PHOSPHATASES
Title (en)
SUBSTRATE TRAPPING PROTEIN TYROSINE PHOSPHATASES
Title (de)
SUBSTRAT FANGENDE PROTEIN TYROSIN PHOSPHATASE
Title (fr)
PROTEINE-TYROSINE-PHOSPHATASES DE PIEGEAGE DE SUBSTRATS
Publication
Application
Priority
- US 0014211 W 20000524
- US 13731999 P 19990603
- US 33457599 A 19990616
Abstract (en)
[origin: WO0075339A1] Compositions and methods are provided pertaining to novel substrate trapping mutant protein tyrosine phosphatases (PTPs) that are catalytically impaired but which retain the ability to bind phosphotyrosine-containing protein substrate(s), and that are further modified by the replacement of at least one tyrosine residue with an amino acid that cannot be phophorylated. Uses of such PTPs for identification of PTP substrates, and of agents that alter PTP-substrate interactions are disclosed, as are methods of altering PTP activities.
IPC 1-7
C12N 15/52; C12N 9/16; C12N 15/62; A61K 38/00; C12N 15/11; G01N 33/566
IPC 8 full level
G01N 33/50 (2006.01); A61K 38/45 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/16 (2006.01); C12N 15/09 (2006.01); C12Q 1/42 (2006.01); G01N 33/15 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12N 9/16 (2013.01); C07K 2319/02 (2013.01)
Citation (search report)
See references of WO 0075339A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0075339 A1 20001214; AU 5284200 A 20001228; CA 2375145 A1 20001214; EP 1187924 A1 20020320; JP 2003501098 A 20030114
DOCDB simple family (application)
US 0014211 W 20000524; AU 5284200 A 20000524; CA 2375145 A 20000524; EP 00937706 A 20000524; JP 2001502601 A 20000524