Global Patent Index - EP 1189632 A4

EP 1189632 A4 20020821 - PNEUMOCOCCAL SURFACE PROTEIN COMBINATION VACCINE

Title (en)

PNEUMOCOCCAL SURFACE PROTEIN COMBINATION VACCINE

Title (de)

VAKZIN AUS EINER KOMBINATIONVON PNEUMOKOKKEN-OBERFLäCHENPROTEINEN

Title (fr)

VACCIN A COMBINAISON DE PROTEINES DE SURFACE PNEUMOCOCCIQUES

Publication

EP 1189632 A4 20020821 (EN)

Application

EP 00947640 A 20000609

Priority

  • US 0040176 W 20000609
  • US 13842299 P 19990610
  • US 58783300 A 20000606

Abstract (en)

[origin: WO0076541A1] The present invention relates to synergistic immunogenic combinations containing two or more pneumococcal surface proteins, including PspA and/or PspC and/or PsaA, advantageously, PspA and PsaA. Also provided are methods of intranasal administration of such immunogenic combinations to reduce nasopharyngeal carriage of pneumococci and methods of use of such immunogenic combinations in the prevention and treatment of <i>S.pneumoniae infection</i>.

IPC 1-7

A61K 39/09

IPC 8 full level

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 39/09 (2006.01); A61K 39/39 (2006.01); A61K 48/00 (2006.01); A61P 11/00 (2006.01); A61P 31/04 (2006.01); A61P 37/04 (2006.01); C07K 14/315 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP US)

A61P 11/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 37/04 (2018.01 - EP); C07K 14/3156 (2013.01 - EP); A61K 39/00 (2013.01 - EP US); A61K 2039/543 (2013.01 - EP)

Citation (search report)

  • [PY] WO 9953940 A1 19991028 - UNIV ALABAMA [US], et al
  • [Y] WO 9414318 A1 19940707 - MEDIMMUNE INC [US], et al
  • [Y] BRILES D E ET AL: "Pneumococcal diversity: considerations for new vaccine strategies with emphasis on pneumococcal surface protein A (PspA).", CLINICAL MICROBIOLOGY REVIEWS. UNITED STATES OCT 1998, vol. 11, no. 4, October 1998 (1998-10-01), pages 645 - 657, XP000946754, ISSN: 0893-8512
  • [Y] SAMPSON ET AL: "Limited Diversity of Streptococcus pneumoniae psaA among Pneumococcal Vaccine Serotypes", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 65, no. 5, May 1997 (1997-05-01), pages 1967 - 1971, XP002108304, ISSN: 0019-9567
  • [Y] BRILES D E ET AL: "PspA, a protection-eliciting pneumococcal protein: immunogenicity of isolated native PspA in mice", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 14, no. 9, 1 June 1996 (1996-06-01), pages 858 - 867, XP004057611, ISSN: 0264-410X
  • [Y] MCDANIEL L S ET AL: "IMMUNIZATION WITH A PLASMID EXPRESSING PNEUMOCOCCAL SURFACE PROTEIN A (PSPA) CAN ELICIT PROTECTION AGAINST FATAL INFECTION WITH STREPTOCOCCUS PNEUMONIAE", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, no. 4, April 1997 (1997-04-01), pages 375 - 377, XP001068798, ISSN: 0969-7128
  • [Y] THARPE ET AL: "Purification and seroreactivity of pneumococcal surface adhesin A (PsaA)", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 3, no. 2, March 1996 (1996-03-01), pages 227 - 229, XP002109329, ISSN: 1071-412X
  • [Y] BRILES D E ET AL: "PSPA AND PSPC: THEIR POTENTIAL FOR USE AS PNEUMOCOCCAL VACCINES", MICROBIAL DRUG RESISTANCE, LIEBERT, US, vol. 3, no. 4, 1997, pages 401 - 408, XP000946756, ISSN: 1076-6294
  • [Y] SAMPSON J S ET AL: "CLONING AND NUCLEOTIDE SEQUENCE ANALYSIS OF PSAA, THE STREPTOCOCCUSPNEUMONIAE GENE ENCODING A 37-KILODALTON PROTEIN HOMOLOGOUS TO PREVIOUSLY REPORTED STREPTOCOCCUS S. ADHESINS", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 62, no. 1, 1994, pages 319 - 324, XP000749404, ISSN: 0019-9567
  • [Y] BROOKS-WALTER A ET AL: "The pspC gene encodes a second pneumococcal surface protein homologous to the gene encoding the protection-eliciting PspA protein of Streptococcus pneumoniae.", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR, vol. 97, 1997, 97th General Meeting of the American Society for Microbiology;Miami Beach, Florida, USA; May 4-8, 1997, 1997, pages 35, XP001083844, ISSN: 1060-2011
  • [T] BRILES D E ET AL: "The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 19, 8 December 2000 (2000-12-08), pages S87 - S95, XP004227955, ISSN: 0264-410X
  • See also references of WO 0076541A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0076541 A1 20001221; AU 6121000 A 20010102; BR 0011478 A 20020319; CA 2379327 A1 20001221; EP 1189632 A1 20020327; EP 1189632 A4 20020821; JP 2003519089 A 20030617; MX PA01012721 A 20041014

DOCDB simple family (application)

US 0040176 W 20000609; AU 6121000 A 20000609; BR 0011478 A 20000609; CA 2379327 A 20000609; EP 00947640 A 20000609; JP 2001502874 A 20000609; MX PA01012721 A 20000609