EP 1189939 A1 20020327 - BH3 MODIFIED PEPTIDES
Title (en)
BH3 MODIFIED PEPTIDES
Title (de)
BH3-MODIFIZIERTE PEPTIDE
Title (fr)
PEPTIDES MODIFIES BH3
Publication
Application
Priority
- US 0017283 W 20000623
- US 14102799 P 19990625
Abstract (en)
[origin: WO0100670A1] The present invention is directed to a peptide of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising said peptide of formula (I), and the use thereof to restore apoptosis in human tumor cells. A compound of formula (I) of the present invention is R-A<1>-A<2>-A<3>-A<4>-A<5>-A<6>-A<7>-A<8>-A<9>-A<10>-A<11>-A<12>-A<13>-A<14>-A<15>-NHR<1> or a pharmaceutically acceptable salt thereof wherein, R is (C1-C5)acyl; A<1> is absent or an aliphatic amino acid; A<2> is absent or is selected from the group consisting of Gly, Ala, Ser, Thr and Asn; A<3> and A<4> are each absent or are each a coded amino acid; A<5> is an aliphatic amino acid; A<6> is Ala or a basic amino acid; A<7> is selected from the group consisting of Ile, Leu, Val, Ser, Thr, Lys and Arg; A<8> is an aliphatic amino acid; A<9> is Gly; A<10> and A<11> are each independently Asp or Glu; A<12> is an aliphatic amino acid Ile, Leu, Met and Val; A<13> is Asp, Glu or Asn; A<14> and A<15> are each independently absent or selected from the group consisting of Ile, Leu, Val, Met, Ser, Thr, Asn, Lys and Arg; and R<1> is (C1-C5)alkyl.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/4747 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 0100670A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0100670 A1 20010104; AU 5761200 A 20010131; CA 2370099 A1 20010104; EP 1189939 A1 20020327; JP 2003507471 A 20030225; NO 20016188 D0 20011218; NO 20016188 L 20020221
DOCDB simple family (application)
US 0017283 W 20000623; AU 5761200 A 20000623; CA 2370099 A 20000623; EP 00943091 A 20000623; JP 2001518657 A 20000623; NO 20016188 A 20011218