EP 1191975 A4 20050525 - IMPROVEMENT OF T CELL MEDIATED IMMUNITY
Title (en)
IMPROVEMENT OF T CELL MEDIATED IMMUNITY
Title (de)
VERBESSERUNG DER T-ZELLIMMUNITÄT
Title (fr)
AMELIORATION DE L'IMMUNITE INDUITE PAR LES LYMPHOCYTES T
Publication
Application
Priority
- AU 0000329 W 20000417
- AU PP977899 A 19990415
Abstract (en)
[origin: WO0062657A2] The present invention provides a method of modifying the T-cell population makeup or increasing the number of T-cells in a subject having depressed or abnormal T-cell population or function, the method comprising disrupting sex steroid signalling to the thymus in the subject. The invention can be used to treat a subject suffering from a wide array of diseases, for example, cancer, HIV infection, autoimmunity and hypersensitivity. In addition, the present invention provides methods for enhancing an immune response to an antigen, treating an autoimmune disease, and decreasing a host-vs-graft reaction in a transplantation donor.
IPC 1-7
IPC 8 full level
A61K 31/167 (2006.01); A61K 31/445 (2006.01); A61K 38/00 (2006.01); A61K 38/04 (2006.01); A61K 38/09 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61K 45/00 (2006.01); A61P 5/02 (2006.01); A61P 5/24 (2006.01); A61P 15/00 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01)
CPC (source: EP KR)
A61K 38/00 (2013.01 - KR); A61K 38/09 (2013.01 - EP); A61K 39/39 (2013.01 - EP); A61P 5/02 (2017.12 - EP); A61P 5/24 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/04 (2017.12 - EP); A61P 37/06 (2017.12 - EP)
Citation (search report)
- [A] WO 9219746 A1 19921112 - CSL LTD [AU]
- [A] WO 8801176 A1 19880225 - BUNGE AUSTRALIA [AU]
- [X] PLOSKER G L ET AL: "Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders.", DRUGS. DEC 1994, vol. 48, no. 6, December 1994 (1994-12-01), pages 930 - 967, XP001202673, ISSN: 0012-6667
- [A] LANDSTRÖM M ET AL: "Apoptosis in rat prostatic adenocarcinoma is associated with rapid infiltration of cytotoxic T-cells and activated macrophages.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. 2 MAY 1997, vol. 71, no. 3, 2 May 1997 (1997-05-02), pages 451 - 455, XP002322556, ISSN: 0020-7136
- See references of WO 0062657A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0062657 A2 20001026; WO 0062657 A3 20010111; AU 3797700 A 20001102; AU 779067 B2 20050106; AU PP977899 A0 19990513; BR 0009712 A 20020430; CA 2370296 A1 20001026; CN 100376288 C 20080326; CN 1364093 A 20020814; EP 1191975 A2 20020403; EP 1191975 A4 20050525; HK 1046249 A1 20030103; JP 2002542174 A 20021210; KR 20020007371 A 20020126; NZ 514975 A 20040326; ZA 200108451 B 20030115
DOCDB simple family (application)
AU 0000329 W 20000417; AU 3797700 A 20000417; AU PP977899 A 19990415; BR 0009712 A 20000417; CA 2370296 A 20000417; CN 00808966 A 20000417; EP 00916705 A 20000417; HK 02107213 A 20020930; JP 2000611797 A 20000417; KR 20017013148 A 20011015; NZ 51497500 A 20000417; ZA 200108451 A 20011015