EP 1194171 A2 20020410 - NITRIC OXIDE-PRODUCING HYDROGEL MATERIALS
Title (en)
NITRIC OXIDE-PRODUCING HYDROGEL MATERIALS
Title (de)
STICKSTOFFMONOXID-FORMENDE HYDROGEL-MATERIALIEN
Title (fr)
MATERIAUX HYDROGELS PRODUISANT DU MONOXYDE D'AZOTE
Publication
Application
Priority
- US 0024058 W 20000901
- US 15205499 P 19990902
Abstract (en)
[origin: WO0115738A2] Hydrogels releasing or producing NO, most preferably photopolymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The hydrogels are typically formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released <i>in situ</i> to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01)
CPC (source: EP)
A61K 47/58 (2017.07); A61K 47/6903 (2017.07)
Citation (search report)
See references of WO 0115738A2
Citation (examination)
US 5797887 A 19980825 - ROSEN GERALD M [US], et al
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT
DOCDB simple family (publication)
WO 0115738 A2 20010308; WO 0115738 A3 20020131; AU 7101600 A 20010326; CA 2353531 A1 20010308; CZ 20011899 A3 20011114; EP 1194171 A2 20020410; IL 143305 A0 20020421; MX PA01005338 A 20030714
DOCDB simple family (application)
US 0024058 W 20000901; AU 7101600 A 20000901; CA 2353531 A 20000901; CZ 20011899 A 20000901; EP 00959750 A 20000901; IL 14330500 A 20000901; MX PA01005338 A 20000901