EP 1194451 A1 20020410 - FUSION PEPTIDES COMPRISING A PEPTIDE LIGAND DOMAIN AND A MULTIMERIZATION DOMAIN
Title (en)
FUSION PEPTIDES COMPRISING A PEPTIDE LIGAND DOMAIN AND A MULTIMERIZATION DOMAIN
Title (de)
FUSIONSPEPTIDE DIE EINE PEPTID-BINDENDE-DOMÄNE UND EINE MULTIMERISIERUNGSDOMÄNE ENTHALTEN
Title (fr)
PEPTIDES DE FUSION COMPRENANT UN DOMAINE LIGAND PEPTIDE ET UN DOMAINE DE MULTIMERISATION
Publication
Application
Priority
- US 0018185 W 20000630
- US 14208899 P 19990702
Abstract (en)
[origin: WO0102440A1] The invention provides novel hybrid molecules comprising a peptide ligand domain which functions to bind a predetermined target molecule and a multimerization domain such as an immunoglobulin constant region domain or a leucine zipper. The hybrid molecules optionally include an additional functional moiety such as an enzyme moiety or a cytotoxic moiety. In preferred embodiments, the hybrid molecules have improved pharmacokinetic or pharmacological properties. The invention further provides for the research, diagnostic and therapeutic use of the hybrid molecules and includes compositions such as pharmaceutical compositions comprising the hybrid molecules.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 14/745 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12N 15/62 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12); C07K 14/70596 (2013.01); C07K 14/71 (2013.01); C07K 14/745 (2013.01); C12N 15/62 (2013.01); A61K 2039/505 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/55 (2013.01); C07K 2319/75 (2013.01)
Citation (search report)
See references of WO 0102440A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0102440 A1 20010111; AU 6064400 A 20010122; CA 2377731 A1 20010111; EP 1194451 A1 20020410; IL 147270 A0 20020814; JP 2003505020 A 20030212
DOCDB simple family (application)
US 0018185 W 20000630; AU 6064400 A 20000630; CA 2377731 A 20000630; EP 00946962 A 20000630; IL 14727000 A 20000630; JP 2001508227 A 20000630