EP 1194561 A2 20020410 - DONOR STRAND COMPLEMENTED PILIN AND ADHESIN BROAD-BASED VACCINES
Title (en)
DONOR STRAND COMPLEMENTED PILIN AND ADHESIN BROAD-BASED VACCINES
Title (de)
IMPFSTOFFE BASIEREND AUF ZUSAMMENSETZUNGEN AUS PILIN UND DIESEN KOMPLEMENTIERENDEN POLYPEPTIDE
Title (fr)
VACCINS DE PILINE ET D'ADHESINE COMPLETES PAR UN BRIN DONNEUR POUR PRODUCTION A GRANDE ECHELLE
Publication
Application
Priority
- US 0019066 W 20000713
- US 14358299 P 19990713
- US 14435999 P 19990716
- US 18444200 P 20000223
Abstract (en)
[origin: WO0104148A2] Modified polypeptides containing a pilus-protein sequence and a donor complementary sequence are disclosed, as well as complexes formed of a modified polypeptide and a pilin, or pilus-protein. Also disclosed are methods of using these novel polypeptides as a means of preventing and/or treating bacterial induced diseases, especially those caused by enterobacteria such as <i>Escherichia coli</i>. Methods of employing these modified pilus-derived polypeptides and complexes as vaccines and for generating antibodies for further study as well as for clinical purposes are also disclosed herein. In addition, processes for large scale production of antibacterial vaccines containing said polypeptides and complexes are also described.
IPC 1-7
C12N 15/31; C12N 15/62; C07K 14/245; C07K 16/12; C07K 19/00; A61K 39/108; A61K 39/40
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/108 (2006.01); A61P 13/02 (2006.01); A61P 31/04 (2006.01); C07K 14/195 (2006.01); C07K 14/245 (2006.01); C07K 16/12 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); A61K 39/00 (2006.01); C12R 1/01 (2006.01)
CPC (source: EP)
A61P 13/02 (2018.01); A61P 31/04 (2018.01); C07K 14/245 (2013.01); A61K 39/00 (2013.01); A61K 2039/505 (2013.01); C07K 2319/00 (2013.01)
Citation (examination)
- SOTO ET AL: "Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus.", EMBO J., vol. 17, no. 21, 1998, pages 6155 - 6167
- LANGERMANN ET AL: "Prevention of Mucosal Escherichia coli Infection by FimH-Adhesin-Based Systemic Vaccination", SCIENCE, vol. 276, 25 April 1997 (1997-04-25), pages 607 - 611
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0104148 A2 20010118; WO 0104148 A3 20010628; WO 0104148 A9 20010726; AU 6094000 A 20010130; CA 2373534 A1 20010118; EP 1194561 A2 20020410; HK 1045713 A1 20021206; JP 2003504083 A 20030204
DOCDB simple family (application)
US 0019066 W 20000713; AU 6094000 A 20000713; CA 2373534 A 20000713; EP 00947305 A 20000713; HK 02106980 A 20020925; JP 2001509757 A 20000713