EP 1196026 A1 20020417 - ANIMAL MODELS AND METHODS FOR ANALYSIS OF LIPID METABOLISM AND SCREENING OF PHARMACEUTICAL AND PESTICIDAL AGENTS THAT MODULATE LIPID METABOLISM
Title (en)
ANIMAL MODELS AND METHODS FOR ANALYSIS OF LIPID METABOLISM AND SCREENING OF PHARMACEUTICAL AND PESTICIDAL AGENTS THAT MODULATE LIPID METABOLISM
Title (de)
TIERMODELE UND VERFAHREN ZUR ANALYSE VON LIPIDMETABOLISMUS UND ZUM SCREENEN VON PHARMACEUTICA UND PESTICIDE MITTELN DIE DAS LIPIDMETABOLISMUS MODULIEREN
Title (fr)
MODELES ANIMAUX ET METHODES D'ANALYSE DU METABOLISME DES LIPIDES ET CRIBLAGE D'AGENTS PHARMACEUTIQUES ET DE PESTICIDES MODULANT LE METABOLISME DES LIPIDES
Publication
Application
Priority
- US 0015880 W 20000608
- US 33252299 A 19990614
- US 18970000 P 20000315
Abstract (en)
[origin: WO0076308A1] Drosophila melanogaster and <i>C. elegans</i> that have been genetically modified to express or mis-express proteins involved in the sterol regulatory element binding protein (SREBP) pathway are described. These genetically modified animal models have identifiable phenotypes that make them useful in assays for studying lipid metabolism, other genes implicated in lipid metabolism, and compounds capable of modulating lipid metabolism pathways. Methods for studying lipid metabolism in living mematodes using fluorescently labeled fatty acid conjugates, such BODIPY<TM> fatty acid conjugates, are also described. Novel SREBP pathway nucleic acid and protein sequences are also described.
IPC 1-7
IPC 8 full level
A01K 67/033 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/92 (2006.01)
CPC (source: EP)
A01K 67/0336 (2013.01); C07K 14/4705 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 0076308A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0076308 A1 20001221; CA 2373628 A1 20001221; EP 1196026 A1 20020417; JP 2003501102 A 20030114
DOCDB simple family (application)
US 0015880 W 20000608; CA 2373628 A 20000608; EP 00939730 A 20000608; JP 2001502665 A 20000608